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Titolo:
Granulocyte colony-stimulating factor administration in human immunodeficiency virus-infected patients with prolonged neutropenia
Autore:
von Wichmann, MA; Camino, X; Txoperena, G; Arrizabalaga, J; Rodriguez-Arrondo, F; Iribarren, JA;
Indirizzi:
Hosp Nuestra Senora Aranzazu, Unidad Enfermedades Infecciosas, San Sebastian 20014, Spain Hosp Nuestra Senora Aranzazu San Sebastian Spain 20014 tian 20014, Spain Hosp Nuestra Senora Aranzazu, Cuidados Med Intens, San Sebastian 20014, Spain Hosp Nuestra Senora Aranzazu San Sebastian Spain 20014 tian 20014, Spain
Titolo Testata:
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
fascicolo: 1, volume: 19, anno: 2001,
pagine: 19 - 23
SICI:
0213-005X(200101)19:1<19:GCFAIH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
SPA
Soggetto:
HIV-INFECTION; BACTERIAL-INFECTION; CONTROLLED TRIAL; G-CSF; BACTEREMIA; FILGRASTIM; CHEMOTHERAPY; SURVIVAL; BLOOD;
Keywords:
granulocyte colony-stimulation factor (G-CSF); neutropenia; HIV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: von Wichmann, MA Hosp Nuestra Senora Aranzazu, Unidad Enfermedades Infecciosas, Paseo Dr Beguiristain S-N, San Sebastian 20014, Spain Hosp Nuestra Senora Aranzazu Paseo Dr Beguiristain S-N San Sebastian Spain 20014
Citazione:
M.A. von Wichmann et al., "Granulocyte colony-stimulating factor administration in human immunodeficiency virus-infected patients with prolonged neutropenia", ENFERM INF, 19(1), 2001, pp. 19-23

Abstract

BACKGROUND. Persistent neutropenia is frequent in HIV infected patients with severe immunodeficiency. G-CSF induces proliferation and differentation of granulocyte precursors. Our objective has been to assess the response toG-CSF therapy on patients with advanced HIV disease and prolonged neutropenia. METHODS. A restrospective analysis of databases containing demographic information, analitic controls and hospitalizations related to neutropenia forpatients attending our Infectious Diseases Unit from Decembre 1, 1992 to January 30, 98. The episodes with absolute neutrophil counts lower than 1,000x10(6) / l at least during 7 days which descend below 500x10(6) / l at anymoment were included. RESULTS. 36 episodes were included. 9 episodes started on treatment with G-CSF. The median duration was 9 (3-76) weeks. Hospitalization with fever related to neutropenia was significantly less frequent in episodes which received G-CSF (22.2%) than episodes without (66.7%). CONCLUSION. In this study, a significantly lower risk of hospitalization due to fever and neutropenia was associated with administration of G-CSF in patients with absolute neutrophil counts lower than 500x106 / l.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:24:53