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Titolo:
Effect of dopamine agonists on lactotroph adenomas of the human pituitary
Autore:
Stefaneanu, L; Kovacs, K; Scheithauer, BW; Kontogeorgos, G; Riehle, DL; Sebo, TJ; Murray, D; Vidal, S; Tran, A; Buchfelder, M; Fahlbusch, R;
Indirizzi:
Univ Toronto, St Michaels Hosp, Dept Lab Med, Div Pathol, Toronto, ON M5B 1W8, Canada Univ Toronto Toronto ON Canada M5B 1W8 athol, Toronto, ON M5B 1W8, Canada Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA Mayo Clin Rochester MN USA lin, Dept Lab Med & Pathol, Rochester, MN USA G Gennimatas Gen Hosp Athens, Dept Pathol, Athens, Greece G Gennimatas GenHosp Athens Athens Greece Dept Pathol, Athens, Greece Univ Erlangen Nurnberg, Dept Neurosurg, Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany pt Neurosurg, Erlangen, Germany
Titolo Testata:
ENDOCRINE PATHOLOGY
fascicolo: 4, volume: 11, anno: 2000,
pagine: 341 - 352
SICI:
1046-3976(200024)11:4<341:EODAOL>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEOPLASTIC HUMAN PITUITARIES; DEPENDENT KINASE INHIBITOR; MONOCLONAL-ANTIBODY KI-67; TUMOR ANGIOGENESIS; CELL-PROLIFERATION; P27(KIP1) EXPRESSION; MICE LACKING; BCL-2 FAMILY; BLOOD-FLOW; BROMOCRIPTINE;
Keywords:
adenomas; dopamine agonists; pituitary; proliferation markers; vasculature;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Stefaneanu, L Univ Toronto, St Michaels Hosp, Dept Lab Med, Div Pathol, 30Bond St, Toronto, ON M5B 1W8, Canada Univ Toronto 30 Bond St Toronto ON Canada M5B 1W8 W8, Canada
Citazione:
L. Stefaneanu et al., "Effect of dopamine agonists on lactotroph adenomas of the human pituitary", ENDOCR PATH, 11(4), 2000, pp. 341-352

Abstract

Dopamine (DA) agonists cause reduction of blood prolactin level and tumor shrinkage in most patients with lactotroph adenoma. Our aim was to investigate the cellular mechanism of tumor shrinkage by determining mitotic, MIB-1, p27, and apoptotic indices, as well as microvessel density (MVD), surfacemicrovessel density (SMD), ploidy, and other nuclear parameters. Surgically removed lactotroph adenomas were selected from 29 patients, of whom 19 were treated with oral bromocriptine (BEC), long-acting injectable BEC (BEC-LAR), or quinagolide and 10 were untreated. In treated adenomas mitotic and MIB-1 indices were lower, whereas the apoptotic indices were not significantly higher compared to untreated adenomas. The decrease in MIB-1 labeling reached significance in adenomas exposed to quinagolide (p < 0.05). Aside from the BEC-LAR treated group, wherein p27 expression was significantly reduced (p < 0.05), p27 expression did not differ significantly between the treated and untreated groups. MVD density was significantly lower in the treated adenomas, whereas the decrease in SMD did not attain significance. The DNA ploidy and most other nuclear parameters did not differ significantly inthe two groups. In conclusion, reduction of mitotic and MIB-1 indices indicates that suppression of cell proliferation contributes to tumor shrinkage, whereas p27 protein expression and apoptosis play no major role in the adenoma involution. Further studies are required to explain the effect of DA agonists on MVD and SMD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 05:53:53