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Titolo:
Neuropeptide Y in central control of feeding and interactions with orexin and leptin
Autore:
Niimi, M; Sato, M; Taminato, T;
Indirizzi:
Kagawa Med Univ, Dept Clin Lab Med, Kagawa 7610793, Japan Kagawa Med UnivKagawa Japan 7610793 Clin Lab Med, Kagawa 7610793, Japan Kagawa Med Univ, Dept Internal Med 1, Kagawa 7610793, Japan Kagawa Med Univ Kagawa Japan 7610793 ternal Med 1, Kagawa 7610793, Japan
Titolo Testata:
ENDOCRINE
fascicolo: 2, volume: 14, anno: 2001,
pagine: 269 - 273
SICI:
1355-008X(200103)14:2<269:NYICCO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED FOOD-INTAKE; RECEPTOR ANTAGONIST; HYPOCRETIN OREXIN; RAT HYPOTHALAMUS; FOS EXPRESSION; OBESE GENE; OB-R; NEURONS; BRAIN; NPY;
Keywords:
neuropeptide Y; orexin; leptin; food intake; Fos; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Niimi, M Kagawa Med Univ, Dept Clin Lab Med, 1750-1 Miki Cho, Kagawa 7610793, Japan Kagawa Med Univ 1750-1 Miki Cho Kagawa Japan 7610793 0793, Japan
Citazione:
M. Niimi et al., "Neuropeptide Y in central control of feeding and interactions with orexin and leptin", ENDOCRINE, 14(2), 2001, pp. 269-273

Abstract

Neuropeptide (NPY) increases feeding when injected into the brain. In thisstudy, we tested the hypothesis that its action might be related to feeding regulation of the orexin and leptin systems in rats. Intracerebroventricular administration of NPY (1 nmol/5 muL) stimulated feeding in rats. Injection of an antibody to orexin-A inhibited feeding, suggesting that endogenous orexin exerts a stimulatory tone on feeding. Intracerebroventricular injection of orexin antiserum before injection of NPY significantly attenuated the feeding response to NPY, On the other hand, ip pretreatment with leptin(2 mg/kg) significantly decreased food intake and inhibited NPY-induced feeding. We then examined whether orexin-containing neurons are activated under the stimulation of feeding in response to intracerebroventricular NPY orsuppression of feeding in response to ip leptin, using Fos-like immunoreactivity (FLI) as a marker of neural activation. We observed that FLI was induced in the paraventricular, supraoptic, and dorsomedial nuclei as well as the lateral hypothalamic area (LHA) following administration of NPY, Doublestaining with anti-fos and anti-orexin antibodies revealed that 23.4% of the orexin-containing neurons in the LHA expressed FLI after NPY injection. Approximately 7.8% of the orexin-positive neurons in the LHA coexpressed Fos after leptin plus NPY, Our data indicate that a functional interaction among NPY, orexin, and leptin exists that may contribute to the central regulation of appetite.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:37:17