Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Endothelin-like immunoreactivity in lactotrophs, gonadotrophs, and somatotrophs of rat anterior pituitary gland are affected differentially by ovarian steroid hormones
Autore:
Kanyicska, B; Lerant, A; Freeman, ME;
Indirizzi:
Florida State Univ, Biomed Res Facil, Dept Biol Sci, Program Neurosci, Tallahassee, FL 32306 USA Florida State Univ Tallahassee FL USA 32306 ci, Tallahassee, FL 32306 USA Univ Mississippi, Med Ctr, Dept Anat, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 r, Dept Anat, Jackson, MS 39216 USA
Titolo Testata:
ENDOCRINE
fascicolo: 2, volume: 14, anno: 2001,
pagine: 263 - 268
SICI:
1355-008X(200103)14:2<263:EIILGA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-HORMONE; TYROSINE-HYDROXYLASE; LUTEINIZING-HORMONE; PROGESTIN RECEPTORS; ESTROGEN-RECEPTOR; BOVINE PITUITARY; TREATED MONKEYS; TARGET-CELLS; PROLACTIN; SECRETION;
Keywords:
endothelin; pituitary; luteinizing hormone; growth hormone; estradiol; progesterone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Kanyicska, B Florida State Univ, Biomed Res Facil, Dept Biol Sci, Program Neurosci, Tallahassee, FL 32306 USA Florida State Univ Tallahassee FL USA 32306 ee, FL 32306 USA
Citazione:
B. Kanyicska et al., "Endothelin-like immunoreactivity in lactotrophs, gonadotrophs, and somatotrophs of rat anterior pituitary gland are affected differentially by ovarian steroid hormones", ENDOCRINE, 14(2), 2001, pp. 263-268

Abstract

It has been previously found that all hormone-producing phenotypes of the anterior lobe of the pituitary gland are capable of producing endothelin (ET)-like substances. The aim of this study was to determine whether the expression of ET-1-like peptides in lactotrophs, gonadotrophs, and somatotrophsis influenced by different in vivo ovarian hormonal conditions. Anterior lobes of the pituitary gland were harvested from ovariectomized and ovarian steroid-replaced adult female rats 10-12 d after surgery. Quantitative immunocytochemistry was performed on enzymatically dispersed pituitary cells. The presence of ET-1-like immunoreactivity in prolactin-, luteinizing hormone-, or growth hormone-producing cells was demonstrated by double-label immunocytochemistry. The incidence of ET-1 immunopositive pituitary cells was unaffected by progesterone treatment alone. Estradiol replacement caused a modest decrease in the number of lactotrophs and somatotrophs expressing ET-1 but increased the incidence of ET-1 immunopositive cells among gonadotrophs, Combined treatment with estradiol and progesterone robustly increased the incidence of ET-1 immunopositive lactotrophs and gonadotrophs but had noeffect on somatotrophs, These data reveal that the synthesis of ET-l-like peptides in lactotrophs and gonadotrophs (and, to a lesser extent, in somatotrophs) is sensitive to ovarian steroids. Furthermore, these findings predict that ovarian steroids modulate ET-1 biosynthesis during the estrous cycle, suggesting a possible mechanism by which the ovarian steroid milieu mayregulate the responsiveness of lactotrophs and gonadotrophs to their hypothalamic secretagogues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:47:23