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Titolo:
Role of chaperones in nuclear translocation and transactivation of steroidreceptors
Autore:
Heinlein, CA; Chang, CS;
Indirizzi:
Univ Rochester, Med Ctr, Dept Pathol, George Whipple Lab Canc Res, Rochester, NY 14642 USA Univ Rochester Rochester NY USA 14642 b Canc Res, Rochester, NY 14642 USA
Titolo Testata:
ENDOCRINE
fascicolo: 2, volume: 14, anno: 2001,
pagine: 143 - 149
SICI:
1355-008X(200103)14:2<143:ROCINT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-SHOCK-PROTEIN; HSP56 IMMUNOPHILIN COMPONENT; RABBIT RETICULOCYTE LYSATE; CELL-FREE SYSTEM; GLUCOCORTICOID RECEPTOR; ANDROGEN RECEPTOR; ESTROGEN-RECEPTOR; PROGESTERONE-RECEPTOR; MOLECULAR CHAPERONES; SIGNAL-TRANSDUCTION;
Keywords:
steroid receptor; chaperone; heat-shock protein; trafficking; ligand affinity;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: Chang, CS Univ Rochester, Med Ctr, Dept Pathol, George Whipple Lab Canc Res, Box 626,601 Elmwood Ave, Rochester, NY 14642 USA Univ Rochester Box 626,601 Elmwood Ave Rochester NY USA 14642 SA
Citazione:
C.A. Heinlein e C.S. Chang, "Role of chaperones in nuclear translocation and transactivation of steroidreceptors", ENDOCRINE, 14(2), 2001, pp. 143-149

Abstract

Molecular chaperones assist proteins to reach their mature and functional conformation. It has become apparent in recent years that chaperones function as part of a multiprotein heterocomplex that is potentially involved notonly in protein folding, but also in intracellular trafficking and in targeting proteins for degradation. In the case of steroid receptors, the activity of the chaperone heterocomplex, as well as the proteins comprising the heterocomplex, has an effect on the observed ligand-dependent transcriptional activity of the receptor. The direct interaction between chaperones and steroid receptors makes them potential therapeutic targets in a number of pathologic conditions. In the case of cancers with steroid receptor involvement, such as breast and prostate cancer, the inhibition of chaperone activity may inhibit tumor cell growth. Conversely, enhancement of chaperone activity may be beneficial in disorders of protein misfolding, as in the case of androgen receptor aggregates found in Spinal and Bulbar Muscular Atrophy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:15:02