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Titolo:
Selective inhibitors of apoptotic caspases: implications for novel therapeutic strategies
Autore:
Nuttall, ME; Lee, D; McLaughlin, B; Erhardt, JA;
Indirizzi:
SmithKline Beecham Pharmaceut, Dept Cardiovasc Pharmacol, King Of Prussia,PA 19406 USA SmithKline Beecham Pharmaceut King Of Prussia PA USA 19406 a,PA 19406 USA SmithKline Beecham Pharmaceut, Dept Med Chem, Redwood City, CA 94063 USA SmithKline Beecham Pharmaceut Redwood City CA USA 94063 ity, CA 94063 USA Univ Pittsburgh, Dept Neurobiol, Pittsburgh, PA 15261 USA Univ PittsburghPittsburgh PA USA 15261 urobiol, Pittsburgh, PA 15261 USA
Titolo Testata:
DRUG DISCOVERY TODAY
fascicolo: 2, volume: 6, anno: 2001,
pagine: 85 - 91
SICI:
1359-6446(20010115)6:2<85:SIOACI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRAUMATIC BRAIN INJURY; DEPRIVED PC12 CELLS; SYMPATHETIC NEURONS; CEREBRAL-ISCHEMIA; CORTICAL-NEURONS; IN-VITRO; DEATH; ACTIVATION; MICE; OSTEOARTHRITIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Nuttall, ME SmithKline Beecham Pharmaceut, Dept Cardiovasc Pharmacol, 709 Swedeland Rd, King Of Prussia, PA 19406 USA SmithKline Beecham Pharmaceut 709 Swedeland Rd King Of Prussia PA USA 19406
Citazione:
M.E. Nuttall et al., "Selective inhibitors of apoptotic caspases: implications for novel therapeutic strategies", DRUG DISC T, 6(2), 2001, pp. 85-91

Abstract

Caspases are essential for apoptosis. A crucial question regarding the role(s) of these proteases is whether the selective inhibition of an effector caspase will prevent cell death. We have identified potent, selective non-peptide inhibitors of the effector caspases 3 and 7. Apoptosis can be inhibited and cell functionality maintained using an inhibitor selective for caspases 3 and 7. This has important therapeutic implications and the potentialto generate novel anti-apoptotic strategies in diseases that involve dysregulated apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:50:10