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Titolo:
Matrix metalloproteinases in cancer invasion, metastasis and angiogenesis
Autore:
Foda, HD; Zucker, S;
Indirizzi:
Vet Adm Med Ctr, Dept Med & Res, Northport, NY 11768 USA Vet Adm Med Ctr Northport NY USA 11768 Med & Res, Northport, NY 11768 USA SUNY Stony Brook, Div Pulm Crit Care Med, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 Med, Stony Brook, NY 11794 USA SUNY Stony Brook, Dept Med Oncol, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 ncol, Stony Brook, NY 11794 USA
Titolo Testata:
DRUG DISCOVERY TODAY
fascicolo: 9, volume: 6, anno: 2001,
pagine: 478 - 482
SICI:
1359-6446(20010501)6:9<478:MMICIM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; C-TERMINAL DOMAIN; TISSUE INHIBITOR; CELL-SURFACE; PROGELATINASE-A; IN-VITRO; INTERSTITIAL COLLAGENASE; 72-KDA GELATINASE; HUMAN LUNG; MEMBRANE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Foda, HD Vet Adm Med Ctr, Dept Med & Res, Northport, NY 11768 USA Vet Adm Med Ctr Northport NY USA 11768 , Northport, NY 11768 USA
Citazione:
H.D. Foda e S. Zucker, "Matrix metalloproteinases in cancer invasion, metastasis and angiogenesis", DRUG DISC T, 6(9), 2001, pp. 478-482

Abstract

Matrix metalloproteinases (MMPs) are a family of proteinases that play an important role in cancer as well as in numerous other diseases. In this article, we summarize the current views on the role of MMPs in cancer with respect to invasion, metastasis and angiogenesis. A positive correlation between tumor progression and the expression of multiple MMP family members in tumor tissues has been demonstrated in numerous human and animal studies. Ithas been assumed that cancer cells are responsible for producing the MMPs in human tumors. However, recent evidence suggests that tumor cells have docking sites that bind stromal-cell-secreted MMPs. Furthermore, the role of MMPs produced by endothelial cells, especially MMP-2 and MT1-MMP, appear tobe crucial for tumor angiogenesis, which is a requirement for cancer growth and dissemination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:07:35