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Titolo:
Acute phase response in laparoscopic and open colectomy in colon cancer - Randomized study
Autore:
Delgado, S; Lacy, AM; Filella, X; Castells, A; Garcia-Valdecasas, JC; Pique, JM; Momblan, D; Visa, J;
Indirizzi:
Univ Barcelona, Hosp Clin, Inst Digest Dis, Dept Gen & Digest Surg, Barcelona, Spain Univ Barcelona Barcelona Spain Dept Gen & Digest Surg, Barcelona, Spain Univ Barcelona, Hosp Clin, Dept Clin Biochem, Barcelona, Spain Univ Barcelona Barcelona Spain lin, Dept Clin Biochem, Barcelona, Spain Univ Barcelona, Hosp Clin, Dept Gastroenterol IMD, Barcelona, Spain Univ Barcelona Barcelona Spain Dept Gastroenterol IMD, Barcelona, Spain
Titolo Testata:
DISEASES OF THE COLON & RECTUM
fascicolo: 5, volume: 44, anno: 2001,
pagine: 638 - 646
SICI:
0012-3706(200105)44:5<638:APRILA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURGICAL STRESS-RESPONSE; OPEN CHOLECYSTECTOMY; HORMONAL RESPONSES; ASSISTED COLECTOMY; SURGERY; INTERLEUKIN-6; TRAUMA; HOSPITALIZATION; ADENOCARCINOMA; EXPERIENCE;
Keywords:
laparoscopic-assisted colectomy; cancer; interleukin-6; C-reactive protein; hormonal response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Lacy, AM Hosp Clin, Dept Gastrointestinal Surg, IMD, Villarroel 170, Barcelona 08036, Spain Hosp Clin Villarroel 170 Barcelona Spain 08036 lona 08036, Spain
Citazione:
S. Delgado et al., "Acute phase response in laparoscopic and open colectomy in colon cancer - Randomized study", DIS COL REC, 44(5), 2001, pp. 638-646

Abstract

All types of trauma to the organism produce a systemic response that is proportional to the severity of the lesion caused. The more rapid clinical recovery during the postoperative period of patients undergoing laparoscopic-assisted colectomy vs. patients receiving conventional surgery suggests that laparoscopic surgery produces less surgical trauma. The aim of this randomized, prospective study was to compare acute phase postoperative response in patients diagnosed with colon neoplasm undergoing open segmentary colectomy vs laparoscopic-assisted colectomy. METHODS: From Tune 1994 to July 1997 the results of 97 patients (58 submitted to open colectomy and 39 undergoing laparoscopic-assisted colectomy) were analyzed. Blood determinations ofcortisol, prolactin. C-reactive protein and interleukin-6 were performed before surgery and at 4, 12, 24, and 72 hours after surgery. RESULTS: The plasma levels of cortisol and prolactin were higher in the postoperative period with both surgical techniques with no significant differences being observed. The levels of interleukin-6 achieved a maximum peak at 4 hours after surgery, later showing a decrease and practically achieving basal levels at72 hours in both groups. The levels of interleukin-6 were higher with significant differences at 4, 12, and 24 hours in the patients undergoing open colectomy. The plasma levels of C-reactive protein were significantly lowerat 72 hours in patients receiving laparoscopic-assisted colectomy. CONCLUSIONS: The results obtained in this randomized, prospective study suggest that acute phase systemic response is attenuated in patients undergoing laparoscopic-assisted colectomy in comparison with patients receiving open colectomy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:44:20