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Titolo:
Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development
Autore:
Al-Shawi, R; Ashton, SV; Underwood, C; Simons, JP;
Indirizzi:
Univ Coll London, Royal Free & Univ Coll Med Sch, Dept Anat & Dev Biol, London NW3 2PF, England Univ Coll London London England NW3 2PF ev Biol, London NW3 2PF, England
Titolo Testata:
DEVELOPMENT GENES AND EVOLUTION
fascicolo: 4, volume: 211, anno: 2001,
pagine: 161 - 171
SICI:
0949-944X(200104)211:4<161:EOTRAR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECESSIVE ROBINOW-SYNDROME; IN-SITU HYBRIDIZATION; BRACHYDACTYLY TYPE-B; NEUROMUSCULAR-JUNCTION; INT-1 PROTOONCOGENE; NERVOUS-SYSTEM; AXON GUIDANCE; FULL-LENGTH; RAT TRKC; FAMILY;
Keywords:
Ror1; Ror2; receptor tyrosine kinases; Robinow syndrome; brachydactyly;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Simons, JP Univ Coll London, Royal Free & Univ Coll Med Sch, Dept Anat & Dev Biol, Royal Free Campus,Rowland Hill St, London NW3 2PF, England Univ Coll London Royal Free Campus,Rowland Hill St London England NW3 2PF
Citazione:
R. Al-Shawi et al., "Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development", DEV GENES E, 211(4), 2001, pp. 161-171

Abstract

Ror1 and Ror2 are orphan receptor tyrosine kinases that are most closely related to MuSK and the Trk family of neurotrophin receptors. We report the re suits of an extensive in situ hybridisation survey of the expression of these genes during mouse development. Expression of Ror1 and Ror2 differs markedly at early stages (E8.5-E9.5). At these times, Ror2 is expressed muchmore widely than Ror1, expression of which is largely restricted to head mesenchyme. At later stages of development (E12.5-E14.5), Ror1 expression expands and Ror2 expression becomes more restricted than at earlier times? although expression of Ror1 continues to be more restricted than that of Ror2. These changes result in overlapping expression domains but with major differences remaining. In many cases Ror1 is expressed in a sub-set of Ror-2-expressing tissues; in others, there is complementary expression of Ror1 andRor2. Ror1 and Ror2 are both expressed in derivatives of all three germ layers and in most organ systems, including the nervous, circulatory, respiratory, digestive, urogenital and skeletal systems. Conspicuous themes are the expression in major sense organs, and in neural crest and its derivatives.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 16:48:21