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Titolo:
Glycyrrhizin restores the impaired IL-12 production in thermally injured mice
Autore:
Utsunomiya, T; Kobayashi, M; Ito, M; Herndon, DN; Pollard, RB; Suzuki, F;
Indirizzi:
Univ Texas, Med Branch, Dept Internal Med, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 t Internal Med, Galveston, TX 77555 USA Shriners Burns Hosp, Galveston, TX 77555 USA Shriners Burns Hosp Galveston TX USA 77555 Hosp, Galveston, TX 77555 USA Yamanashi Med Univ, Dept Microbiol, Tamaho, Yamanashi, Japan Yamanashi MedUniv Tamaho Yamanashi Japan biol, Tamaho, Yamanashi, Japan
Titolo Testata:
CYTOKINE
fascicolo: 1, volume: 14, anno: 2001,
pagine: 49 - 55
SICI:
1043-4666(20010407)14:1<49:GRTIIP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCYTE CHEMOATTRACTANT PROTEIN-1; SIMPLEX VIRUS TYPE-1; CANDIDA-ALBICANS INFECTION; CONTRASUPPRESSOR T-CELLS; STAPHYLOCOCCUS-AUREUS; CD4(+) LYMPHOCYTES; PROSTAGLANDIN E-2; IMMUNE-RESPONSES; ACTIVE COMPONENT; LICORICE ROOTS;
Keywords:
glycyrrhizin; IL-12; burn-associated type 2 T cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, F Univ Texas, Med Branch, Dept Internal Med, 301 Univ Blvd, Galveston, TX 77555 USA Univ Texas 301 Univ Blvd Galveston TX USA 77555 on, TX 77555 USA
Citazione:
T. Utsunomiya et al., "Glycyrrhizin restores the impaired IL-12 production in thermally injured mice", CYTOKINE, 14(1), 2001, pp. 49-55

Abstract

Mice 6 days after thermal injury (TI-mice) did not respond to lipopolysaccharide (LPS) stimulation for production of serum interleukin 12 (IL-12; 2 hafter LPS stimulation, < 20 pg/ml in TI-mice; 1091 +/- 162pg/ml in normal mice). However, 2h after LPS stimulation, 1456 +/- 118 pg/ml of IL-12 were demonstrated in sera of TI-mice previously treated with a 10 mg/kg i.p. dose of glycyrrhizin (GR), IL-12 was not induced by LPS in sera of normal miceinoculated with burn-associated type 2 T cells (IL-4/IL-10-producing CD8(+) CD11b(+) TCR gamma/delta (+) T cells isolated from spleens of TI-mice), However, IL-12 production was induced by LPS in sera of these mice previously treated with GR or a mixture of monoclonal antibodies (mAbs) for type 2 cytokines, Also, IL-12 production was induced by LPS in TI-mice inoculated with CD4(+) T cells from spleens of GR-treated normal mice (GR-CD4(+) T cells, 5 x 10(6) cells/mouse), Since GR-CD4(+) T cells have been shown to be antagonistic cells against production of type 2 cytokines by burn-associated type 2 T cells, these results indicate that IL-12 unresponsiveness shown inTI-mice is recovered by GR through the regulation of burn-associated type 2 -T cell responses. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:42:42