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Titolo:
Effect of carnosine administration on metabolic parameters in bilharzia-infected hamsters
Autore:
Soliman, K; El-Ansary, A; Mohamed, AM;
Indirizzi:
Cairo Univ, Fac Med, Dept Biochem, Cairo, Egypt Cairo Univ Cairo EgyptCairo Univ, Fac Med, Dept Biochem, Cairo, Egypt Natl Res Ctr, Dept Med Chem, Cairo, Egypt Natl Res Ctr Cairo EgyptNatl Res Ctr, Dept Med Chem, Cairo, Egypt
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
fascicolo: 1, volume: 129, anno: 2001,
pagine: 157 - 164
SICI:
1096-4959(200105)129:1<157:EOCAOM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENERGY-METABOLISM; HISTIDINE; ANSERINE; RAT;
Keywords:
carnosine; Schistosoma mansoni; lipid peroxides; energy charge;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Soliman, K Fac Med, Anim House, Cairo, Egypt Fac Med Anim House Cairo Egypt Med, Anim House, Cairo, Egypt
Citazione:
K. Soliman et al., "Effect of carnosine administration on metabolic parameters in bilharzia-infected hamsters", COMP BIOC B, 129(1), 2001, pp. 157-164

Abstract

Carnosine is a naturally occurring dipeptide (beta -alanyl-L-histidine) found in muscles, brain and other tissues. This study was designed to test the ability of carnosine to offset metabolic disturbances induced by Schistosoma mansoni parasitism. Results indicate that parasitic infection caused elevation of liver weight/body weight in S. mansoni-infected hamsters, induced lipid peroxidation and reduced glycogen levels. Moreover, adenylate energy charge (AEC) and ATP/ADP and ATP/AMP concentration ratios were markedly lower in infected hamsters. Administration of carnosine (10 mg/day) for 15 days concurrent with infection effectively reduced worm burden and egg count. Administration of carnosine 2 and 4 weeks post-exposure only partially ameliorated the S. mansoni effects on metabolism. Carnosine treatment also normalized most of the parameters measured, including glycogen repletion, theantioxidant status and AEC. These finding support the use of carnosine forpossible intervention in schistosomiasis. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 19/09/20 alle ore 21:14:46