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Titolo:
Treatment of Alzheimer's disease with cholinesterase inhibitors
Autore:
Schneider, LS;
Indirizzi:
Univ So Calif, Keck Sch Med, Dept Psychiat, Los Angeles, CA 90033 USA UnivSo Calif Los Angeles CA USA 90033 sychiat, Los Angeles, CA 90033 USA Univ So Calif, Keck Sch Med, Dept Behav Sci & Neurol, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 Neurol, Los Angeles, CA 90033 USA Univ So Calif, Leonard Davis Sch Gerontol, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 erontol, Los Angeles, CA 90033 USA
Titolo Testata:
CLINICS IN GERIATRIC MEDICINE
fascicolo: 2, volume: 17, anno: 2001,
pagine: 337 -
SICI:
0749-0690(200105)17:2<337:TOADWC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; PLACEBO-CONTROLLED TRIAL; RANDOMIZED CONTROLLED TRIAL; DOUBLE-BLIND; CHOLINERGIC SYSTEM; GLOBAL FUNCTION; OPEN-LABEL; TACRINE; METRIFONATE; DONEPEZIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Schneider, LS Univ So Calif, Keck Sch Med, Dept Psychiat, 1975 Zonal Ave,KAM-400, Los Angeles, CA 90033 USA Univ So Calif 1975 Zonal Ave,KAM-400 Los Angeles CA USA 90033
Citazione:
L.S. Schneider, "Treatment of Alzheimer's disease with cholinesterase inhibitors", CLIN GERIAT, 17(2), 2001, pp. 337

Abstract

This article reviews the present status of cholinesterase inhibitors (ChIs) for the treatment of Alzheimer's disease (AD). It then discusses treatment approaches and current and future issues with respect to efficacy and safety. The cholinergic system has long been recognized as the most severely affected neurotransmitter system in AD, and therapeutic strategies were developed to restore cholinergic function. Although agents with various kinds of procholinergic action have been evaluated for efficacy in AD, the ChIs are the only agents consistently to have demonstrated efficacy in numerous multicenter, placebo-controlled trials and to have been approved by many nationalregulatory authorities.(35)Cholinesterase inhibitors represent the first class of efficacious pharmacologic approaches for AD, and an approach that is likely to be useful clinically for the indefinite future, especially because research on drugs with other mechanisms has not advanced as rapidly as had been hoped.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:29:45