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Titolo:
The role of neuroimaging in dementia
Autore:
DeCarli, C;
Indirizzi:
Univ Calif Davis, Dept Neurol, Sacramento, CA 95817 USA Univ Calif Davis Sacramento CA USA 95817 Neurol, Sacramento, CA 95817 USA
Titolo Testata:
CLINICS IN GERIATRIC MEDICINE
fascicolo: 2, volume: 17, anno: 2001,
pagine: 255 -
SICI:
0749-0690(200105)17:2<255:TRONID>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTED-TOMOGRAPHY; ALZHEIMERS-DISEASE; TEMPORAL-LOBE; CEREBRAL ATROPHY; BRAIN ATROPHY; WHITE-MATTER; LEWY BODIES; FRONTOTEMPORAL DEMENTIA; INTERNATIONAL WORKSHOP; HIPPOCAMPAL-FORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: DeCarli, C Univ Calif Davis, Dept Neurol, 4860 Y St,Suite 3700, Sacramento, CA 95817 USA Univ Calif Davis 4860 Y St,Suite 3700 Sacramento CA USA 95817 A
Citazione:
C. DeCarli, "The role of neuroimaging in dementia", CLIN GERIAT, 17(2), 2001, pp. 255

Abstract

Current advances in our understanding of the various dementias, and Alzheimer's disease (AD) in particular, have led to a high level of clinical diagnostic accuracy. Although much of our information about diagnostic accuracyis derived from research center experience, clinical accuracy for AD is consistently above 85% and has been reported to achieve levels of accuracy above 90%. Although clinical diagnostic accuracy may be somewhat lower in a community setting and in very early stages of AD, current clinical standardsare moving toward an inclusive approach to making the diagnosis of AD. Much of the change in diagnostic focus reflects our ability to treat the disease. Neuroimaging technology is playing a greater role in assisting the clinician with the diagnosis of various dementing disorders. A variety of methods both sensitive and specific to the anatomic or physiologic brain changes now known to accompany various dementing disorders are generally available. These methods include high-resolution brain structural imaging with MR imaging or CT, and functional neuroimaging techniques, such as single photon emission CT (SPECT) and positron emission tomography (PET). In addition to clinical application for the diagnosis of dementia, these techniques also offer the opportunity to examine structural, functional, and biochemical changes in the brain leading to new insights regarding the pathophysiology of thevarious dementias. This article focuses primarily on AD, but includes comment on other dementias, especially with regard to using neuroimaging as a tool for differential diagnosis. The article begins with a brief review of the pathologic brainchanges that accompany AD and the technical aspects of the currently available neuroimaging technologies. The body of the article focuses on the clinical applications of these methods for the diagnosis of various dementing illnesses. Some promising new methods of image analysis and exciting new technologies are introduced at the end of the article.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:13:15