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Titolo:
Carbohydrate and fat have different effects on plasma leptin concentrations and adipose tissue leptin production
Autore:
Evans, K; Clark, ML; Frayn, KN;
Indirizzi:
Staffordshire Gen Hosp, Dept Clin Chem, Stafford ST16 3SA, England Staffordshire Gen Hosp Stafford England ST16 3SA fford ST16 3SA, England Radcliffe Infirm, Oxford Lipid Metab Grp, Oxford OX2 6HE, England Radcliffe Infirm Oxford England OX2 6HE tab Grp, Oxford OX2 6HE, England
Titolo Testata:
CLINICAL SCIENCE
fascicolo: 5, volume: 100, anno: 2001,
pagine: 493 - 498
SICI:
0143-5221(200105)100:5<493:CAFHDE>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBESE GENE-EXPRESSION; OB GENE; NEUROPEPTIDE-Y; BODY-WEIGHT; FOOD-INTAKE; INSULIN; HUMANS; METABOLISM; INDUCTION; EMULSION;
Keywords:
carbohydrate; fat; leptin; postprandial;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Evans, K Staffordshire Gen Hosp, Dept Clin Chem, Stafford ST16 3SA, England Staffordshire Gen Hosp Stafford England ST16 3SA 6 3SA, England
Citazione:
K. Evans et al., "Carbohydrate and fat have different effects on plasma leptin concentrations and adipose tissue leptin production", CLIN SCI, 100(5), 2001, pp. 493-498

Abstract

Leptin is secreted by adipocytes and plays a role in the regulation of food intake. However, the regulation of leptin production by adipose tissue isunclear. We have investigated whether a mixed meal or a high-fat load given orally, or a pure fat load given intravenously, stimulates adipose tissueleptin production. Six volunteers were studied on two occasions following an overnight fast. On one occasion they consumed tomato soup containing 40 g of triacylglycerol (as Intralipid) and 9.6 g of carbohydrate; on the other occasion Intralipid was infused intravenously over 4 h to give the same fat load. A further eight subjects consumed a mixed meal (containing 37 g offat and 100 g of carbohydrate) after an overnight fast. pal red blood samples were obtained from an arterialized hand vein and a vein draining subcutaneous adipose tissue at baseline and for 6 h following the meals or the start of the infusion. After both the intravenous and oral fat loads, the arterialized and adipose venous plasma leptin concentrations decreased over 6 h (both P < 0.001), as did the leptin veno-arterial difference (P = 0.01). Following the mixed meal, there was a slight increase in the arterialized plasma leptin concentration (P = 0.02) and a more marked increase in the adipose venous plasma leptin concentration (P = 0.03) and in the adipose tissue leptin veno-arterial difference (P = 0.01), all peaking at 240 min. We conclude that the increase in plasma leptin concentration observed after meals is not sim ply a result of an energy load, but is in response to a signalthat is not present following a fat load without carbohydrate.

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Documento generato il 19/01/20 alle ore 00:53:26