Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Role of early diagnosis and aggressive surgery in the management of invasive pulmonary aspergillosis in neutropenic patients
Autore:
Caillot, D; Mannone, L; Cuisenier, B; Couaillier, JF;
Indirizzi:
Univ Hosp Dijon, Dept Clin Hematol, Dijon, France Univ Hosp Dijon Dijon France sp Dijon, Dept Clin Hematol, Dijon, France Univ Hosp Dijon, Lab Mycol, Dijon, France Univ Hosp Dijon Dijon FranceUniv Hosp Dijon, Lab Mycol, Dijon, France Univ Hosp Dijon, Dept Radiol, Dijon, France Univ Hosp Dijon Dijon France niv Hosp Dijon, Dept Radiol, Dijon, France
Titolo Testata:
CLINICAL MICROBIOLOGY AND INFECTION
, volume: 7, anno: 2001, supplemento:, 2
pagine: 54 - 61
SICI:
1198-743X(2001)7:<54:ROEDAA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CT HALO SIGN; MARROW TRANSPLANT RECIPIENTS; LIPOSOMAL AMPHOTERICIN-B; AIR CRESCENT SIGN; ACUTE-LEUKEMIA; FUNGAL-INFECTIONS; IMMUNOCOMPROMISED PATIENTS; ITRACONAZOLE THERAPY; SURGICAL-MANAGEMENT; LIPID COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Caillot, D Ctr Hosp Univ, Hematol Clin, F-21034 Dijon, France Ctr Hosp Univ Dijon France F-21034 lin, F-21034 Dijon, France
Citazione:
D. Caillot et al., "Role of early diagnosis and aggressive surgery in the management of invasive pulmonary aspergillosis in neutropenic patients", CL MICRO IN, 7, 2001, pp. 54-61

Abstract

Invasive pulmonary aspergillosis (IPA) occurs mostly in immunocompromised hosts and especially in neutropenic patients. Improved prognosis for IPA requires early diagnosis. We report our experience in the management of IPA in patients with hematological malignancies. In prolonged neutropenia (> 10 days), thoracic CT scanning seems to be the best choice for the diagnosis of IPA (with CT halo or air-crescent signs). Its systematic use allows a dramatic reduction in the time to achieve the diagnosis, if there is evidence of a halo sign. The systematic screening for the detection of Aspergillus antigenemia with an ELISA test is helpful for early diagnosis. The detectionof Aspergillus antigen (with the less sensitive latex agglutination test) on bronchoalveolar lavage (DAL) fluid may also he as useful. The treatment of IPA relies on amphotericin B (or its lipid formulations) or on azole antifungal agents. Pulmonary surgical resection should be considered either asan emergency procedure (despite persistent neutropenia) to avoid massive hemoptysis. or as an elective or diagnostic procedure. This global strategy for the management of IPA is associated with a 75-80% success rate in hematological patients. Nevertheless. the control of underlying: malignancy remains a major prognostic factor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 08:44:39