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Titolo:
Telomere shortening and decreased replicative potential, contrasted by continued proliferation of telomerase-positive CD8(+)CD28(lo) T cells in patients with systemic lupus erythematosus
Autore:
Honda, M; Mengesha, E; Albano, S; Nichols, WS; Wallace, DJ; Metzger, A; Klinenberg, JR; Linker-Israeli, M;
Indirizzi:
Cedars Sinai Res Inst, Dept Med, Los Angeles, CA 90048 USA Cedars Sinai Res Inst Los Angeles CA USA 90048 Los Angeles, CA 90048 USA Univ Calif Los Angeles, Los Angeles, CA 90048 USA Univ Calif Los Angeles Los Angeles CA USA 90048 Los Angeles, CA 90048 USA
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 2, volume: 99, anno: 2001,
pagine: 211 - 221
SICI:
1521-6616(200105)99:2<211:TSADRP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC STEM-CELLS; CD28 EXPRESSION; RHEUMATOID-ARTHRITIS; HUMAN-LYMPHOCYTES; CUTTING EDGE; ACTIVATION; SENESCENCE; MEMORY; LENGTH; DNA;
Keywords:
SLE; T lymphocyte aging; telomere length; autoimmunity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Linker-Israeli, M Cedars Sinai Med Ctr, D-5078,8700 Beverly Blvd, Los Angeles, CA 90048 USA Cedars Sinai Med Ctr D-5078,8700 Beverly Blvd Los AngelesCA USA 90048
Citazione:
M. Honda et al., "Telomere shortening and decreased replicative potential, contrasted by continued proliferation of telomerase-positive CD8(+)CD28(lo) T cells in patients with systemic lupus erythematosus", CLIN IMMUNO, 99(2), 2001, pp. 211-221

Abstract

To evaluate whether the immune system of systemic lupus erythematosus (SLE) patients shows features of premature aging, we compared telomere length and proliferative potential of SLE peripheral blood mononuclear cells (PBMC)(N = 90) to those of controls (N = 64). SLE samples showed accelerated loss of telomeric DNA (P = 0.00008) and higher levels of senescent (less than or equal to5 kb) telomeric DNA (P = 0.00003). Viability cell counts and CFSE tracking in 6-week-old cell cultures indicated that SLE PBMC (CD8(+) and CD4(+) T cells) underwent fewer mitotic cycles and had shorter telomeres than controls (P = 0.04). However, a CD8(+)CD28(lo) T cell subset expanded preferentially in SLE-derived bulk cultures (P = 0.0009), preserved telomericDNA (P = 0.01 vs entire CD8(+)), and displayed telomerase activity [2.1 telomerase arbitrary units (TAU) vs 0.5 TAU in CD8(+)CD28(hi) cells and 0.3 TAU in bulk PBMC; P = 0.05]. These T cell anomalies could be due to chronic in vivo stimulation of the immune system and may contribute to the immune dysregulation found in SLE. (C) 2001 Academic Press.

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Documento generato il 24/01/20 alle ore 15:24:17