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Titolo:
Hyperglycaemia: A morphine-like effect produced by naloxone
Autore:
Abouazra, HA; Sharif, SI;
Indirizzi:
Al Arab Med Univ, Fac Med, Dept Pharmacol, Benghazi, Libya Al Arab Med Univ Benghazi Libya ac Med, Dept Pharmacol, Benghazi, Libya
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 4, volume: 28, anno: 2001,
pagine: 300 - 305
SICI:
0305-1870(200104)28:4<300:HAMEPB>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-2-ADRENOCEPTOR ANTAGONIST; ADRENERGIC-RECEPTORS; CONSCIOUS RABBITS; BLOOD-GLUCOSE; INSULIN; MICE; HYPOGLYCEMIA; HYPERTENSION; SPECIFICITY; INVOLVEMENT;
Keywords:
alpha-adrenoceptor; blood glucose level; hyperglycaemia; naloxone; rabbits; WB-4101; yohimbine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Abouazra, HA Univ Malaya, Fac Med, Dept Pharmacol, Kuala Lumpur 50603, Malaysia Univ Malaya Kuala Lumpur Malaysia 50603 pur 50603, Malaysia
Citazione:
H.A. Abouazra e S.I. Sharif, "Hyperglycaemia: A morphine-like effect produced by naloxone", CLIN EXP PH, 28(4), 2001, pp. 300-305

Abstract

1. Naloxone, which is often regarded as a pure opioid antagonist, produceseffects similar to those produced by morphine.2. In conscious rabbits implanted with an intracerebroventricular (i.c.v.)cannula, naloxone, whether given intravenously (1 mg/kg) or i.c.v. (1-100 mug), produced a significant rise in blood glucose levels.3. Hyperglycaemia in response to naloxone (1 mg/kg, i.v., or 100 mug, i.c.v,) was not influenced by the selective alpha (1)-adrenoceptor antagonist WB-4101 given either i.v. (50 mug) or i.c.v. (5 mug).4. Hyperglycaemia in response to naloxone (1 mg/kg, i.v., or 100 mug, i.c.v.) was completely blocked by pretreatment with the alpha (2)-adrenoceptor antagonist yohimbine (1 mg/kg, i.v., or 100 mug, i.c.v.). However, hyperglycaemia to i.c.v, naloxone (100 mug) was not influenced by i.v. yohimbine (1mg/kg).5. Because naloxone behaves like morphine and produces hyperglycaemia in conscious rabbits, the drug may have an appreciable agonist activity and thehyperglycaemic response to naloxone is principally mediated via alpha (2)-but not alpha (1)-adrenoceptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:19:35