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Titolo:
Chronic administration of docosahexaenoic acid improves the performance ofradial arm maze task in aged rats
Autore:
Gamoh, S; Hashimoto, M; Hossain, S; Masumura, S;
Indirizzi:
Shimane Med Univ, Dept Physiol, Izumo, Shimane 6938501, Japan Shimane Med Univ Izumo Shimane Japan 6938501 zumo, Shimane 6938501, Japan Meiji Pharmaceut Univ, Dept Pharmacol, Kiyose, Japan Meiji Pharmaceut Univ Kiyose Japan Univ, Dept Pharmacol, Kiyose, Japan
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 4, volume: 28, anno: 2001,
pagine: 266 - 270
SICI:
0305-1870(200104)28:4<266:CAODAI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM DEPRESSION; ALPHA-LINOLENIC ACID; LEARNING-ABILITY; BRAIN PHOSPHOLIPIDS; ALZHEIMERS-DISEASE; HIPPOCAMPUS; MEMORY; POTENTIATION; DEFICIENCY; NEURONS;
Keywords:
aged rats; docosahexaenoic acid; hippocampus; lipid peroxide; spatial memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Hashimoto, M Shimane Med Univ, Dept Physiol, Izumo, Shimane 6938501, JapanShimane Med Univ Izumo Shimane Japan 6938501 6938501, Japan
Citazione:
S. Gamoh et al., "Chronic administration of docosahexaenoic acid improves the performance ofradial arm maze task in aged rats", CLIN EXP PH, 28(4), 2001, pp. 266-270

Abstract

1. In the present study, we investigated the effect of docosahexaenoic acid (DHA) on spatial memory related learning ability in aged (100 weeks) maleWistar rats.2. Rats were fed a fish oil-deficient diet through three generations and were then randomly divided into two groups. Over 10 weeks, one group was perorally administered 300 mg/kg per day DHA dissolved in 5% gum Arabic solution and the other group was administered the vehicle alone. Five weeks after the start of the administration, rats were tested with the partially baited eight-arm radial maze to estimate two types of spatial memory related learning ability displayed by reference memory error and working memory error.3. Chronic administration of DHA significantly decreased the number of reference memory errors and working memory errors.4. The level of lipid peroxide (LPO) in the hippocampus tended to decreasewith chronic DHA administration and demonstrated a positive correlation with the number of reference memory errors.5. These results suggest that the accumulation of hippocampal LPO reduces spatial memory related learning ability in aged rats. Moreover, chronic administration of DHA was effective in decreasing the level of hippocampal LPO, then improving learning ability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 12:56:49