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Titolo:
Two possible mechanisms underlying nitrate tolerance in monkey coronary arteries
Autore:
Omura, T; Matsumoto, T; Nakae, I; Takahashi, M; Kinoshita, M;
Indirizzi:
Shiga Univ Med Sci, Dept Internal Med 1, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 1, Otsu, Shiga 5202192, Japan
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 4, volume: 28, anno: 2001,
pagine: 259 - 265
SICI:
0305-1870(200104)28:4<259:TPMUNT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL-NATRIURETIC-PEPTIDE; VASCULAR SMOOTH-MUSCLE; ENDOTHELIUM-INDEPENDENT RELAXATION; PARTICULATE GUANYLATE-CYCLASE; CYCLIC-GMP ACCUMULATION; NITRIC-OXIDE FORMATION; GLYCERYL TRINITRATE; SODIUM-NITROPRUSSIDE; ORGANIC NITRATES; RELAXING FACTOR;
Keywords:
atrial natriuretic peptide; cyclic GMP; monkey; nitric oxide; nitroglycerin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Matsumoto, T Shiga Univ Med Sci, Dept Internal Med 1, Otsu, Shiga 5202192,Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 a 5202192, Japan
Citazione:
T. Omura et al., "Two possible mechanisms underlying nitrate tolerance in monkey coronary arteries", CLIN EXP PH, 28(4), 2001, pp. 259-265

Abstract

1. Previous studies using isolated arteries have demonstrated cross-tolerance between nitric oxide (NO) donors such as nitroglycerin (NTG) and sodiumnitroprusside (SNP). However, it remains unclear whether the vasorelaxing effect of atrial natriuretic peptide (ANP), an activator of particulate guanylate cyclase, is affected by treatment with NO donors. To investigate thecross-tolerance and interactions between NTG and ANP in coronary vasorelaxant responses, we used two models of monkey coronary arterial strips (Macaca fuscata).2. In one model, which was induced by a 1 h treatment with 4.4 x 10(-4) mol/L NTG followed by washout of the agent for 1 h, the vasorelaxing effects of subsequent NTG were markedly attenuated, whereas those of ANP and NO were not affected. These findings suggest that the development of NTG tolerance is associated with a biotransformation process from NTG to NO. In the other model, which did not include washout after exposure to 3 x 10(-6) mol/L NTG, the vasorelaxant responses to 10(-8) mol/L ANP (31.1 +/- 5.4 vs 5.1 +/- 2.1%, respectively; P < 0.001), 10(-6) mol/L NO (61.5 +/- 4 vs 29.5 +/- 8.5%, respectively; P < 0.001) and 10(-8) mol/L SNP (49.4 +/- 6.4 vs 8.0 +/-2.0%, respectively; P < 0.001) were significantly attenuated. The concentration-response curve for 8-bromo-cGMP (8-Br-cGMP) was shifted to the right,whereas responses to papaverine and forskolin were unchanged. These findings suggest that an intracellular process that occurs after the synthesis ofcGMP is responsible for this interaction.3. As a mechanism of NTG tolerance, two possible processes may be impaired: (i) biotransformation from NTG to NO; and (ii) an intracellular process that occurs after the synthesis of cGMP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:30:19