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Titolo:
Allergen-induced bronchial inflammation is associated with decreased levels of surfactant proteins A and D in a murine model of asthma
Autore:
Wang, JY; Shieh, CC; Yu, CK; Lei, HY;
Indirizzi:
Natl Cheng Kung Univ, Med Ctr, Dept Paediat, Div Clin Immunol, Tainan 70428, Taiwan Natl Cheng Kung Univ Tainan Taiwan 70428 n Immunol, Tainan 70428, Taiwan Natl Cheng Kung Univ, Coll Med, Dept Microbiol & Immunol, Tainan 70101, Taiwan Natl Cheng Kung Univ Tainan Taiwan 70101 & Immunol, Tainan 70101, Taiwan
Titolo Testata:
CLINICAL AND EXPERIMENTAL ALLERGY
fascicolo: 4, volume: 31, anno: 2001,
pagine: 652 - 662
SICI:
0954-7894(200104)31:4<652:ABIIAW>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY SURFACTANT; LYMPHOCYTE-PROLIFERATION; DERMATOPHAGOIDES-FARINAE; HISTAMINE-RELEASE; GUINEA-PIGS; COLLECTINS; BINDING; LIPOPOLYSACCHARIDES; DYSFUNCTION; EXPRESSION;
Keywords:
airway allergic inflammation; surfactant proteins; bronchial asthma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, JY Natl Cheng Kung Univ, Med Ctr, Dept Paediat, Div Clin Immunol, No138,Sheng Li Rd, Tainan 70428, Taiwan Natl Cheng Kung Univ No 138,Sheng LiRd Tainan Taiwan 70428 iwan
Citazione:
J.Y. Wang et al., "Allergen-induced bronchial inflammation is associated with decreased levels of surfactant proteins A and D in a murine model of asthma", CLIN EXP AL, 31(4), 2001, pp. 652-662

Abstract

Background Increasing evidence suggests that pulmonary surfactant protein A (SP-A) and D (SP-D) participate in the lung defence against pathogens. However, the role of surfactant proteins in the pathogenesis of allergen-induced airway inflammation has not been elucidated. In this study we examined the levels and distributions of SP-A and SP-D in a dust mite (Dermatophagoides pteronyssinus, Der p) allergen-induced murine model of asthma. Methods The concentration of SP-A and SP-D in the bronchoalveolar lavage fluid (BALF) and the distribution of surfactant proteins in the lung were assayed by ELISA and immunohistochemistry methods, respectively. The effect of surfactant proteins on allergen-induced pulmonary lymphocyte proliferation was also studied. Results We demonstrated that there were marked reductions of SP-A and SP-Dlevels in the BALF of Der p-sensitized BALB/c mice at 48-72 h after allergen challenge (AC). Both purified SP-A and SP-D were able to suppress, in a dose dependent manner, Der p-stimulated intrapulmonary lymphocyte proliferation of naive mice with saline or allergen challenge, or of Der p-sensitized mice with saline challenge. On the contrary, this suppressive effect was mild (< 9%) on lymphocytes from sensitized mice after AC. Conclusion These results indicated the involvement of pulmonary surfactantproteins in the allergic bronchial inflammation of sensitized mice.

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Documento generato il 28/11/20 alle ore 23:35:58