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Titolo:
In vivo airway eosinophil accumulation induced by polymyxin-B reduces bronchial responsiveness in guinea pigs
Autore:
Ishiura, Y; Fujimura, M; Myou, S; Nobata, K; Liu, Q; Yamamori, C; Amemiya, T;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Internal Med 3, Kanazawa, Ishikawa 920, JapanKanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan
Titolo Testata:
CLINICAL AND EXPERIMENTAL ALLERGY
fascicolo: 4, volume: 31, anno: 2001,
pagine: 644 - 651
SICI:
0954-7894(200104)31:4<644:IVAEAI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASTHMATIC SUBJECTS; MAST-CELLS; HYPERREACTIVITY; HISTAMINE; HYPERRESPONSIVENESS; BRONCHOCONSTRICTION; COUGH; DRUGS;
Keywords:
polymyxin-B; airway eosinophil accumulation; bronchial responsiveness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Ishiura, Y Wajima Municipal Hosp, Div Pulm Med, 1-1 Yamgishi Machi, WajimaCity, Ishikawa 9288585, Japan Wajima Municipal Hosp 1-1 Yamgishi Machi Wajima City Ishikawa Japan 9288585
Citazione:
Y. Ishiura et al., "In vivo airway eosinophil accumulation induced by polymyxin-B reduces bronchial responsiveness in guinea pigs", CLIN EXP AL, 31(4), 2001, pp. 644-651

Abstract

Background Chronic desquamative eosinophilic bronchitis and bronchial hyperresponsiveness have been considered essential for bronchial asthma. However, it has not been studied whether airway eosinophils enhance or inhibit bronchial responsiveness in vivo. Objective This study was conducted to elucidate the influence of airway eosinophil accumulation on bronchial responsiveness in vivo. Materials and methods Guinea pigs were transnasally treated with 75 mug/kgof polymyxin-B or vehicle twice a week for a total of 3 weeks. Guinea pigswere surgically cannulated and artificially ventilated 24 h after the lastadministration of polymyxin-B or vehicle. Ten minutes after the installation of artificial ventilation, ascending doses of methacholine, acetylcholine or histamine were inhaled for 20 s at intervals of 5 min. Subsequent study was conducted 20 min after treatment of 60 mg/kg of indomethacin in the same manner. Final study was conducted in naive guinea pigs after single inhalation of 75 mug/mL of polymyxin B. Results The proportion of eosinophils in bronchoalveolar lavage fluid significantly increased in guinea pigs treated with polymyxin-B compared with vehicle. Bronchial responsiveness to inhaled methacholine, acetylcholine andhistamine was significantly decreased by the polymyxin-B treatment. This protective effect induced by polymyxin B was abolished by pretreatment of indomethacin. A significant increase in bronchial responsiveness was observedafter a single inhalation of polymyxin B. Conclusion These results suggest that in vivo airway eosinophils may reduce non-specific bronchial responsiveness through inhibitory or bronchoprotective prostanoids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:16:15