Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Differential role of CD80 and CD86 on alveolar macrophages in the presentation of allergen to T lymphocytes in asthma
Autore:
Balbo, P; Silvestri, M; Rossi, GA; Crimi, E; Burastero, SE;
Indirizzi:
San Raffaele Sci Inst, Dept Biol & Technol Res, I-20132 Milan, Italy San Raffaele Sci Inst Milan Italy I-20132 hnol Res, I-20132 Milan, Italy Univ Genoa, Chair Resp Physiol, Genoa, Italy Univ Genoa Genoa ItalyUniv Genoa, Chair Resp Physiol, Genoa, Italy G Gaslini Sci Inst, Genoa, Italy G Gaslini Sci Inst Genoa ItalyG Gaslini Sci Inst, Genoa, Italy Osped di Cattinara, AOR 11, Vercelli, Italy Osped di Cattinara Vercelli Italy di Cattinara, AOR 11, Vercelli, Italy
Titolo Testata:
CLINICAL AND EXPERIMENTAL ALLERGY
fascicolo: 4, volume: 31, anno: 2001,
pagine: 625 - 636
SICI:
0954-7894(200104)31:4<625:DROCAC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGEN-PRESENTING CELL; B7-2 CD86; B-CELLS; HYPERSENSITIVITY PNEUMONITIS; AIRWAY HYPERRESPONSIVENESS; COSTIMULATORY MOLECULES; PULMONARY SARCOIDOSIS; ATOPIC ASTHMATICS; BRONCHIAL-ASTHMA; EXPRESSION;
Keywords:
allergy; monocytes; macrophages; antigen presentation; costimulatory molecules; lung; asthma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Burastero, SE San Raffaele Sci Inst, Dept Biol & Technol Res, Via Olgettina 58, I-20132 Milan, Italy San Raffaele Sci Inst Via Olgettina 58 Milan Italy I-20132
Citazione:
P. Balbo et al., "Differential role of CD80 and CD86 on alveolar macrophages in the presentation of allergen to T lymphocytes in asthma", CLIN EXP AL, 31(4), 2001, pp. 625-636

Abstract

In the asthmatic lung the altered expression of costimulatory molecules (CD80, CD86) by alveolar macrophages contributes to T lymphocyte activation and expansion. We hypothesized that CD80 and CD86 on alveolar macrophages could differentially support allergic inflammation in adult asthma. Here we studied 11 subjects with mild allergic asthma and 11 atopic non-asthmatics as controls. Dermatophagoides-specific T cell lines were derived from peripheral blood from each subject. Bronchoalveolar lavage with evaluation of lung inflammatory cells was performed in all individuals at baseline and 24 h after allergen challenge. The expression of CD80 and CD86 costimulatory molecules by alveolar macrophages was studied and, in parallel, the efficiencyof antigen presentation was measured in terms of IL-4 and IL-5 production by allergen-stimulated autologous T cells. We found that in asthmatic subjects (i) the percent of CD80(+), but not CD86(+) alveolar macrophages was increased at baseline and did not change following allergen challenge; (ii) CD86, but not CD80, membrane expression was up-regulated following allergen challenge; (iii) both CD80 and CD86 were required to support Th2 cytokine production by allergen-specific T cells, with a prevalent role of CD86 afterallergen challenge. Our data indicate that alveolar macrophages deliver costimulatory signals via CD80 and CD86, which support the production of Th2 cytokines by allergen-specific T cells. They also indicate that CD86 in vivo is up-regulated in the 24 h following allergen exposure and that this modulation is functionally relevant.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 16:11:37