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Titolo:
Canine parvovirus (CPV) vaccination: Comparison of neutralizing antibody responses in pups after inoculation with CPV2 or CPV2b modified live virus vaccine
Autore:
Pratelli, A; Cavalli, A; Martella, V; Tempesta, M; Decaro, N; Carmichael, LE; Buonavoglia, C;
Indirizzi:
Univ Bari, Fac Vet Med, Dept Hlth & Anim Well Being, I-70010 Valenzano, BA, Italy Univ Bari Valenzano BA Italy I-70010 Being, I-70010 Valenzano, BA, Italy Cornell Univ, Coll Vet Med, James A Baker Inst Anim Hlth, Ithaca, NY 14853USA Cornell Univ Ithaca NY USA 14853 aker Inst Anim Hlth, Ithaca, NY 14853USA
Titolo Testata:
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
fascicolo: 3, volume: 8, anno: 2001,
pagine: 612 - 615
SICI:
1071-412X(200105)8:3<612:CP(VCO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESTRICTION ENZYME ANALYSIS; FELINE PANLEUKOPENIA VIRUS; HEMORRHAGIC ENTERITIS; DOG-RESPONSE; STRAINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Pratelli, A Univ Bari, Fac Vet Med, Dept Hlth & Anim Well Being, Strada Casamassima Km3, I-70010 Valenzano, BA, Italy Univ Bari Strada Casamassima Km3 Valenzano BA Italy I-70010 y
Citazione:
A. Pratelli et al., "Canine parvovirus (CPV) vaccination: Comparison of neutralizing antibody responses in pups after inoculation with CPV2 or CPV2b modified live virus vaccine", CL DIAG LAB, 8(3), 2001, pp. 612-615

Abstract

Canine parvovirus type 2 (CPV2) emerged in 1978 as causative agent of a new disease of dogs. New antigenic variants (biotypes), designated CPV2a and CPV2b, became widespread during 1979 to 1980 and 1984, respectively. At thepresent time the original CPV2 has disappeared in the dog population and has been replaced by the two new viruses, In the present study the comparison of neutralizing antibody titers in two groups of pups (18 pups in each group) inoculated with CPV2 and CPV2b modified live virus vaccines is reported. Using the hemagglutination inhibition (HI) test, relevant differences between antibody titers, against either the homologous or the heterologous virus, were not constantly observed, Using the neutralization (Nt) test, however, the pups inoculated with CPV2 had antibody titers which were approximately 30 times higher to the homologous virus (mean, 4,732) than to the heterologous virus (CPV2b) (mean, 162), The results of these experiments support two conclusions: (i) the HI test may not always accurately evaluate the true immune status of dogs with respect to CPV, and (ii) dogs inoculated with CPV2 vaccine develop relatively low Nt antibody titers against the heterologous virus (CPV2b), These data may suggest an advantage for new vaccines,considering that most presently licensed vaccines are produced with CPV2, which no longer exists in the dog population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:30:20