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Titolo:
Type 1 fimbriation and its phase switching in diarrheagenic Escherichia coli strains
Autore:
Iida, K; Mizunoe, Y; Wai, SN; Yoshida, S;
Indirizzi:
Kyushu Univ, Fac Med Sci, Dept Bacteriol, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 Dept Bacteriol, Fukuoka 8128582, Japan Umea Univ, Dept Microbiol, S-90187 Umea, Sweden Umea Univ Umea Sweden S-90187 Univ, Dept Microbiol, S-90187 Umea, Sweden
Titolo Testata:
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
fascicolo: 3, volume: 8, anno: 2001,
pagine: 489 - 495
SICI:
1071-412X(200105)8:3<489:T1FAIP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE LARGE-INTESTINE; BIOFILM FORMATION; FIM SWITCH; I PILI; EXPRESSION; PROTEIN; INFECTIONS; ADHERENCE; ADHESINS; O157-H7;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Mizunoe, Y Kyushu Univ, Fac Med Sci, Dept Bacteriol, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 iol, Fukuoka 8128582, Japan
Citazione:
K. Iida et al., "Type 1 fimbriation and its phase switching in diarrheagenic Escherichia coli strains", CL DIAG LAB, 8(3), 2001, pp. 489-495

Abstract

Type 1 fimbriae can be expressed by most Escherichia coli strains and mediate mannose-sensitive (MS) adherence to mammalian epithelial cells. However, the role of type 1 fimbriae in enteric pathogenesis has been unclear. Expression of type 1 fimbriae in E, coli is phase variable and is associated with the inversion of a short DNA element (fim switch). Forty-six strains ofdiarrheagenic E. call were examined for the expression of type L fimbriae. Only four of these strains were originally type 1 fimbriated. Seventeen strains, originally nonfimbriated, expressed type 1 fimbriae in association with off-to-on inversion of the fim switch, after serial passages in static culture. The switching frequencies of these strains, from fimbriate to nonfimbriate, were greater than that of the laboratory strain E. coli K-12. None of the 16 strains of serovar O157:H7 or O157:H- expressed type 1 fimbriaeafter serial passages in static culture. The nucleotide sequence analysis of the fim switch region revealed that all of the O157:H7 and O157:H- strains had a 16-bp deletion in the invertible element, and the pm switch was Locked in the "off" orientation. The results suggest that expression of type 1 fimbriae may be regulated differently in different E. call pathogens causing enteric infections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:22:31