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Titolo:
Effect of intranasal administration of Lactobacillus casei Shirota on influenza virus infection of upper respiratory tract in mice
Autore:
Hori, T; Kiyoshima, J; Shida, K; Yasui, H;
Indirizzi:
Yakult Cent Inst Microbiol Res, Kunitachi, Tokyo 1868650, Japan Yakult Cent Inst Microbiol Res Kunitachi Tokyo Japan 1868650 68650, Japan
Titolo Testata:
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
fascicolo: 3, volume: 8, anno: 2001,
pagine: 593 - 597
SICI:
1071-412X(200105)8:3<593:EOIAOL>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-GAMMA; LYMPH-NODE; T-CELLS; A VIRUS; INTERLEUKIN-12; REPLICATION; PROTECTION; CLEARANCE; LUNG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Hori, T Yakult Cent Inst Microbiol Res, 1796 Yaho, Kunitachi, Tokyo 1868650, Japan Yakult Cent Inst Microbiol Res 1796 Yaho Kunitachi Tokyo Japan 1868650
Citazione:
T. Hori et al., "Effect of intranasal administration of Lactobacillus casei Shirota on influenza virus infection of upper respiratory tract in mice", CL DIAG LAB, 8(3), 2001, pp. 593-597

Abstract

In mice administered Lactobacillus casei strain Shirota (LcS) intranasally, potent induction of interleukin 12, gamma interferon, and tumor necrosis factor alpha, which play a very important role in excluding influenza virus(IFV), was evident in mediastinal lymph node cells. In this model of upperrespiratory IFV infection, the titers of virus in the nasal wash of mice inoculated with 200 mug of LcS for three consecutive days (LcS 200 group) before infection were significantly (P < 0.01) lower than those of mice not inoculated with LcS (control group) (10(0.9 +/- 0.6) versus 10(2.1 +/- 1.0)). The IFV titer was decreased to about 1/10 of the control level. Using this infection model with modifications, we investigated whether the survival rate of mice was increased by intranasal administration of LcS. The survival rate of the mice in the LcS 200 group was significantly (P < 0.05) greater than that of the mice in the control group (69% versus 15%). It seems that the decrease in the titer of virus in the upper respiratory tract to 1/10of the control level was important in preventing death, These findings suggest that intranasal administration of LcS enhances cellular immunity in the respiratory tract and protects against influenza virus infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:12:43