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Titolo:
Tumor specific activation of the VEGF/KDR angiogenic pathway in a subset of locally advanced squamous cell head and neck carcinomas
Autore:
Giatromanolaki, A; Koukourakis, MI; Sivridis, E; Thorpe, PE; Brekken, RA; Konstantinos, S; Fountzilas, G; Gatter, KC; Harris, AL;
Indirizzi:
Democritus Univ Thrace, Dept Pathol, Tumour & Angiogenesis Res Grp, Alexandroupolis, Greece Democritus Univ Thrace Alexandroupolis Greece , Alexandroupolis, Greece Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 Ctr, Dept Pharmacol, Dallas, TX 75235 USA Aristotelian Univ Salonika, AHEPA Hosp, Dept Med Oncol, GR-54006 Salonika,Greece Aristotelian Univ Salonika Salonika Greece GR-54006 4006 Salonika,Greece Oxford Radcliffe Hosp, Dept Cellular Sci, Oxford, England Oxford RadcliffeHosp Oxford England Dept Cellular Sci, Oxford, England Oxford Radcliffe Hosp, Imperial Canc Res Fund, Med Oncol Unit, Oxford, England Oxford Radcliffe Hosp Oxford England d, Med Oncol Unit, Oxford, England Democritus Univ Thrace, Dept Surg, Alexandroupolis, Greece Democritus UnivThrace Alexandroupolis Greece , Alexandroupolis, Greece Democritus Univ Thrace, Dept Radiat Oncol, Alexandroupolis, Greece Democritus Univ Thrace Alexandroupolis Greece , Alexandroupolis, Greece
Titolo Testata:
CLINICAL & EXPERIMENTAL METASTASIS
fascicolo: 4, volume: 18, anno: 2000,
pagine: 313 - 319
SICI:
0262-0898(2000)18:4<313:TSAOTV>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; HUMAN COLON-CANCER; WILD-TYPE P53; FACTOR EXPRESSION; THYMIDINE PHOSPHORYLASE; BREAST-CANCER; LUNG-CANCER; IONIZING-RADIATION; FACTOR GENE; IN-VITRO;
Keywords:
angiogenesis; flk-1 (KDR); head and neck cancer; p53; thymidine phosphorylase; VEGF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Koukourakis, MI Tumour & Angiogenesis Res Grp, 18 Dimokratias Ave, Iraklion 71306, Crete, Greece Tumour & Angiogenesis Res Grp 18 Dimokratias Ave Iraklion Crete Greece 71306
Citazione:
A. Giatromanolaki et al., "Tumor specific activation of the VEGF/KDR angiogenic pathway in a subset of locally advanced squamous cell head and neck carcinomas", CLIN EXP M, 18(4), 2000, pp. 313-319

Abstract

Vascular endothelial growth factor (VEGF) and its receptors, Flt-1 and flk-1(KDR), constitute an important angiogenic pathway which, under hypoxic conditions, is up-regulated in many solid tumours. We used the monoclonal antibody 11B5, specific for recognizing VEGF expression and the `VEGF/flk-1(KDR) complex' on tumour endothelium, to assess free VEGF protein expression and VEGF/receptor activated microvessel density (aMVD) in a series of 104 inoperable locally advanced squamous cell carcinomas of the head and neck, treated with chemo-radiotherapy. High VEGF expression in cancer cells was strongly associated with high VEGF/receptor expression in the vasculature. Thehigh VEGF expression and the aMVD were not associated with the standard microvessel density (sMVD), as assessed with the monoclonal antibody anti-CD31 and, were not detected in normal tissue. An increased sMVD, however, was significantly related with the expression thymidine phosphorylase (TP), andalso with the nuclear accumulation of the oncoprotein p53, but neither p53nor TP was associated with VEGF expression by cancer cells or VEGF/receptor complex aMVD. In 35% of cancer cases examined, more than 20% of the microvessels assessed with anti-CD31 also expressed the VEGF/KDR complex. The vasculature of the normal head and neck mucosa did not express the VEGF/KDR complex. There was no association between VEGF expression or VEGF/receptor complex aMVD and response to chemo-radiotherapy or patient's survival. It isconcluded that activation of the angiogenic pathway VEGF/flk-1(KDR) is tumor specific in a subgroup of locally advanced squamous cell carcinomas of the head and neck. Selective destruction of this type of vasculature, using immunoconjugates directed against the VEGF/receptor complex, may prove therapeutically useful for patients with a high tumoral VEGF/flk-1(KDR) activated microvessel fraction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:34:01