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Titolo:
Rapid senescence induced by overexpression of p53 in NIH3T3 cells
Autore:
Hu, JC; Lei, Y; Hong, X; Lu, ZG; Zhai, ZH;
Indirizzi:
Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China Peking Univ Beijing Peoples R China 100871 ijing 100871, Peoples R China
Titolo Testata:
CHINESE SCIENCE BULLETIN
fascicolo: 8, volume: 46, anno: 2001,
pagine: 653 -
SICI:
1001-6538(200104)46:8<653:RSIBOO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPLICATIVE SENESCENCE; TUMOR SUPPRESSION; HUMAN FIBROBLASTS; IN-VIVO; GROWTH; CULTURE;
Keywords:
p53; p53Val135; NIH3T3; senescence; overexpression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Zhai, ZH Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China Peking Univ Beijing Peoples R China 100871 871, Peoples R China
Citazione:
J.C. Hu et al., "Rapid senescence induced by overexpression of p53 in NIH3T3 cells", CHIN SCI B, 46(8), 2001, pp. 653

Abstract

An NIH3T3 cell line which overexpresses temperature-sensitive p53Val135 was constructed by introduction of p53Val135 gene, It exhibited rapidly characteristic morphological and biochemical alterations related to replicative senescence when being cultured in 32 degreesC. We suggested that the overexpression of p53 activated probably the onset of senescence in NIH3T3 cells,which induced a rapid cellular senescence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:29:15