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Titolo:
Genetics of autism
Autore:
Cook, EH;
Indirizzi:
Univ Chicago, Dept Psychiat, Comm Genet Pharmacol, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 Genet Pharmacol, Chicago, IL 60637 USA Univ Chicago, Dept Pediat, Comm Genet Pharmacol, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 Genet Pharmacol, Chicago, IL 60637 USA Univ Chicago, Dept Pediat, Comm Clin Pharmacol, Chicago, IL 60637 USA UnivChicago Chicago IL USA 60637 m Clin Pharmacol, Chicago, IL 60637 USA Univ Chicago, Dept Psychiat, Comm Clin Pharmacol, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 m Clin Pharmacol, Chicago, IL 60637 USA
Titolo Testata:
CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA
fascicolo: 2, volume: 10, anno: 2001,
pagine: 333 -
SICI:
1056-4993(200104)10:2<333:GOA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERVASIVE DEVELOPMENTAL DISORDERS; SEROTONIN TRANSPORTER 5-HTT; DEPENDENT DIABETES-MELLITUS; INFANTILE-AUTISM; LINKAGE-DISEQUILIBRIUM; PSYCHIATRIC-DISORDERS; FAMILY HISTORY; MULTIPLEX FAMILIES; PROXIMAL 15Q; NEUROPSYCHIATRIC DISORDERS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
127
Recensione:
Indirizzi per estratti:
Indirizzo: Cook, EH Univ Chicago, Dept Psychiat, Comm Genet Pharmacol, MC 3077,5841 SMarylandAve, Chicago, IL 60637 USA Univ Chicago MC 3077,5841 S Maryland Ave Chicago IL USA 60637 USA
Citazione:
E.H. Cook, "Genetics of autism", CH ADOLESC, 10(2), 2001, pp. 333

Abstract

Autism is one of the most strongly heritable complex genetic medical disorders, with heritability stronger than diabetes, asthma, and multiple sclerosis. Similar to these other disorders, autism is a syndrome of heterogeneous etiology. The most common specific etiology appears to be maternally inherited duplications of 15q11-q13, but these only account for 1% to 3% of cases of autism. For most cases of autism, estimates of no fewer than two and possibly more than 20 autism-susceptibility genes acting in concert have been proposed, based on the available data. Several genome-wide screens have been conducted, as have several family-based, controlled association studies. No specific variant has been identified for which there is certainty of its involvement in autism, but it is likely that the first confirmed autism-susceptibility gene variant will be identified from one of the currently identified regions or genes of interest during the current decade. Clinical implications of genetic research, including recurrence risk estimates and screening procedures, are reviewed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:15:49