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Titolo:
The nature and heritability of attention-deficit/hyperactivity disorder
Autore:
Faraone, SV; Doyle, AE;
Indirizzi:
Massachusetts Gen Hosp, Child Psychiat Serv, Clin & Res Program Pediat Psychopharmacol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 harmacol, Boston, MA 02114 USA Harvard Univ, Sch Med, Inst Psychiat Epidemiol & Genet, Dept Psychiat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 net, Dept Psychiat, Boston, MA 02115 USA Massachusetts Mental Hlth Ctr, Boston, MA 02115 USA Massachusetts Mental Hlth Ctr Boston MA USA 02115 r, Boston, MA 02115 USA
Titolo Testata:
CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA
fascicolo: 2, volume: 10, anno: 2001,
pagine: 299 -
SICI:
1056-4993(200104)10:2<299:TNAHOA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIT-HYPERACTIVITY DISORDER; CATECHOL-O-METHYLTRANSFERASE; DOPAMINE TRANSPORTER GENE; HAPLOTYPE RELATIVE RISK; LEARNING-DISABILITIES; FAMILIAL ASSOCIATION; TOURETTE-SYNDROME; BEHAVIOR PROBLEMS; MATERNAL SMOKING; MORPHOMETRIC ANALYSIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
135
Recensione:
Indirizzi per estratti:
Indirizzo: Faraone, SV Massachusetts Gen Hosp, Child Psychiat Serv, Clin & Res Program Pediat Psychopharmacol, 55 Fruit St,Warren 705, Boston, MA 02114 USA Massachusetts Gen Hosp 55 Fruit St,Warren 705 Boston MA USA 02114
Citazione:
S.V. Faraone e A.E. Doyle, "The nature and heritability of attention-deficit/hyperactivity disorder", CH ADOLESC, 10(2), 2001, pp. 299

Abstract

This article reviews family, twin, and adoption studies, along with segregation analyses and molecular genetic studies, suggesting that both genetic and environmental factors contribute to the etiology of ADHD. Findings alsoindicate that the genetic mechanisms that predispose individuals to ADHD are likely to be complex, and the literature on ADHD raises many questions regarding clinical and pathophysiologic heterogeneity of the disorder. Although there is no single pathophysiologic profile of ADHD, data do implicate dysfunction in the frontosubcortical pathways that control attention and motor behavior. Moreover, the effectiveness of stimulants, along with animal models of hyperactivity, point to catecholamine dysregulation as at least one source of ADHD brain dysfunction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 14:06:30