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Titolo:
Targeting of olfactory neurons
Autore:
Strotmann, J;
Indirizzi:
Univ Stuttgart Hohenheim, Inst Physiol, D-70593 Stuttgart, Germany Univ Stuttgart Hohenheim Stuttgart Germany D-70593 93 Stuttgart, Germany
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 4, volume: 58, anno: 2001,
pagine: 531 - 537
SICI:
1420-682X(200104)58:4<531:TOON>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PUTATIVE PHEROMONE RECEPTORS; ODORANT RECEPTORS; FUNCTIONAL-ORGANIZATION; VOMERONASAL SYSTEM; ADENYLYL-CYCLASE; MULTIGENE FAMILY; G-PROTEINS; BULB; RAT; EXPRESSION;
Keywords:
axon guidance; coding; gene targeting; glomerulus; odorant receptor; olfaction; olfactory bulb; projection;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Strotmann, J Univ Stuttgart Hohenheim, Inst Physiol, Garbenstr 30, D-70593Stuttgart, Germany Univ Stuttgart Hohenheim Garbenstr 30 Stuttgart Germany D-70593
Citazione:
J. Strotmann, "Targeting of olfactory neurons", CELL MOL L, 58(4), 2001, pp. 531-537

Abstract

Olfactory sensory neurons detect an enormous variety of small volatile molecules with extremely high sensitivity and specificity. The actual recognition and discrimination of odorous compounds is accomplished by specific receptor proteins located in the ciliary membrane of the sensory neurons. Axonal connections into the olfactory bulb, the first relay station for odor processing in the brain, are organized such that all neurons expressing the same odorant receptor converge their axone onto common glomeruli which are located at similar positions in all individuals from one species. For the establishment of this precise targeting of olfactory axons to their appropriate glomeruli, combinatorial functions of axon-associated cell adhesion molecules and odorant receptor proteins appear to be required. Odorants that stimulate distinct receptor cell populations will thereby activate a specificcombination of glomeruli in the bulb; this characteristic activity patternmay be used by the system to encode the quality of a particular odorant.

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Documento generato il 07/07/20 alle ore 05:05:09