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Titolo:
Immunohistochemical detection of myogenic cells in muscles of fetal and neonatal lambs
Autore:
McCoard, SA; McNabb, WC; Birtles, MJ; Harris, PM; McCutcheon, SN; Peterson, SW;
Indirizzi:
AgRes, Grasslands Res Ctr, Nutr & Behav Grp, Palmerston North, New ZealandAgRes Palmerston North New Zealand v Grp, Palmerston North, New Zealand Massey Univ, Inst Vet Anim & Biomed Sci, Palmerston North, New Zealand Massey Univ Palmerston North New Zealand Palmerston North, New Zealand Massey Univ, Vice Chancellors Off, Palmerston North, New Zealand Massey Univ Palmerston North New Zealand Palmerston North, New Zealand
Titolo Testata:
CELLS TISSUES ORGANS
fascicolo: 1, volume: 169, anno: 2001,
pagine: 21 - 33
SICI:
1422-6405(2001)169:1<21:IDOMCI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE SKELETAL-MUSCLE; SATELLITE CELLS; REGULATORY FACTORS; CELLULAR GROWTH; SOLEUS MUSCLE; MYOD PROTEIN; RAT SOLEUS; FIBER-TYPE; M-CADHERIN; MICE;
Keywords:
fetus; neonate; muscle; satellite cells; MyoD; sheep;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: McNabb, WC AgRes, Grasslands Res Ctr, Nutr & Behav Grp, Private Bag 11008,PalmerstonNorth, New Zealand AgRes Private Bag 11008 Palmerston North NewZealand Zealand
Citazione:
S.A. McCoard et al., "Immunohistochemical detection of myogenic cells in muscles of fetal and neonatal lambs", CELLS T ORG, 169(1), 2001, pp. 21-33

Abstract

Previous studies have implied that myonuclei accumulation in a muscle is more important than myofibre number in the determination of muscle size in fetal/neonatal lambs. However, due to the lack of a reliable marker, the role of myogenic precursor nuclei (satellite cells) in myofibre hypertrophy inlate fetal and postnatal life is not well understood. In this study, MyoD was shown to be a useful marker for actively proliferating satellite cells in both fetal and neonatal lambs. MyoD was used to determine whether there were differences in the number of actively proliferating satellite cells between single and twin fetuses/neonates, which may explain at least some of the difference in myofibre size observed near birth. Eighteen single-bearing and 9 twin-bearing Coopworth ewes were randomly assigned to one of three slaughter groups (100, 120 and 140 days of Elestation) The remaining ewes were kept on pasture until 20 days postpartum at which time 4 single and 4 twin lambs were sacrificed. Twin fetuses/neonates had lower body weights andmuscle weights compared to singles. Lower muscle weights in the twins wereassociated with smaller myofibre cross-sectional areas and lower total nuclei numbers and myogenic precursor cell numbers per muscle in selected hind-limb muscles. These results indicate that myofibre hypertrophy in late gestation and early postnatal life is related to myogenic precursor cell number which may have important implications for growth potential of the growth-restricted fetus. Copyright (C) 2001 S. Karger AG,Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:11:30