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Titolo:
Increased QT dispersion in patients with Prinzmetal's variant angina and cardiac arrest
Autore:
Parchure, N; Batchvarov, V; Malik, M; Camm, AJ; Kaski, JC;
Indirizzi:
St George Hosp, Sch Med, Dept Cardiol Sci, Coronary Artery Dis Res Unit, London SW17 0RE, England St George Hosp London England SW17 0RE es Unit, London SW17 0RE, England
Titolo Testata:
CARDIOVASCULAR RESEARCH
fascicolo: 2, volume: 50, anno: 2001,
pagine: 379 - 385
SICI:
0008-6363(200105)50:2<379:IQDIPW>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; CORONARY-ARTERY DISEASE; LONG-TERM PROGNOSIS; CLINICAL CHARACTERISTICS; SUDDEN-DEATH; VASOSPASTIC ANGINA; VENTRICULAR ARRHYTHMIAS; MANUAL MEASUREMENT; HEALTHY-SUBJECTS; ISCHEMIA;
Keywords:
coronary disease; QT dispersion; sudden death; ventricular arrhythmias;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Kaski, JC St George Hosp, Sch Med, Dept Cardiol Sci, Coronary Artery Dis Res Unit, Cranmer Terrace, London SW17 0RE, England St George Hosp Cranmer Terrace London England SW17 0RE England
Citazione:
N. Parchure et al., "Increased QT dispersion in patients with Prinzmetal's variant angina and cardiac arrest", CARDIO RES, 50(2), 2001, pp. 379-385

Abstract

Objectives: We sought to compare QT dispersion in patients presenting withPrinzmetal's variant angina complicated by cardiac arrest or syncope and patients with uncomplicated variant angina. Background: Despite the usually benign course of treated Prinzmetal's variant angina, a proportion of vasospastic angina patients develop ventricular arrhythmias and sudden death in association with coronary spasm. Increased QT dispersion has been suggestedto increase susceptibility to ventricular arrhythmias in patients with coronary artery spasm. Methods: We studied 25 consecutive patients (mean age 58 years; 14 men) with classical Prinzmetal's variant angina and documented coronary artery spasm. None of the patients had coronary artery stenoses less than or equal to 40%. Five patients had suffered a documented cardiac arrest, two had recurrent syncope and 18 had no arrhythmic events or syncopalepisodes. In all patients QT dispersion (QT maximum-QT minimum in every ECG lead) was measured on the baseline 12-lead electrocardiogram at study entry using a digitising board. Results: Mean (+/-S.D. ) QT dispersion of studypatients was 62.3 +/- 19.5 ms. QT dispersion in patients with cardiac arrest and syncope (79.4 +/- 17.3 ms) was significantly higher compared to patients with no such events (56.3 +/- 16.9 ms). (95% CI 7.5-38.8, P=0.005). Nosignificant clinical, biochemical or angiographic differences were found between patients with and those without cardiac arrest or syncope. Conclusion: QT dispersion is increased in patients with Prinzmetal's variant angina complicated by cardiac arrest and syncope compared to patients without suchevents. Increased QT dispersion may be both a substrate for sudden cardiacdeath and a marker of risk in patients with Prinzmetal's variant angina. (C) 2001 Elsevier Science B;V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:09:46