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Titolo:
Systematic review of the prospective cohort studies on meat consumption and colorectal cancer risk: A meta-analytical approach
Autore:
Sandhu, MS; White, IR; McPherson, K;
Indirizzi:
Univ Cambridge, Dept Publ Hlth & Primary Care, Inst Publ Hlth, StrangewaysRes Lab, Cambridge CB1 8RN, England Univ Cambridge Cambridge England CB1 8RN Lab, Cambridge CB1 8RN, England Univ Cambridge, MRC, Biostat Unit, Inst Publ Hlth, Cambridge CB2 2SR, England Univ Cambridge Cambridge England CB2 2SR lth, Cambridge CB2 2SR, England Univ London London Sch Hyg & Trop Med, Canc & Publ Hlth Unit, London WC1E 7HT, England Univ London London Sch Hyg & Trop Med London England WC1E 7HT T, England
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 5, volume: 10, anno: 2001,
pagine: 439 - 446
SICI:
1055-9965(200105)10:5<439:SROTPC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-NITROSO COMPOUNDS; DOSE-RESPONSE DATA; COLON-CANCER; MEASUREMENT ERROR; UNITED-STATES; RED MEAT; METAANALYSIS; WOMEN; DIET; FIBER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Sandhu, MS Univ Cambridge, Dept Publ Hlth & Primary Care, Inst Publ Hlth, StrangewaysRes Lab, Worts Causeway, Cambridge CB1 8RN, England Univ Cambridge Worts Causeway Cambridge England CB1 8RN ngland
Citazione:
M.S. Sandhu et al., "Systematic review of the prospective cohort studies on meat consumption and colorectal cancer risk: A meta-analytical approach", CANC EPID B, 10(5), 2001, pp. 439-446

Abstract

The relation between meat consumption and colorectal cancer risk remains controversial. In this report, we quantitatively reviewed the prospective observational studies that have analyzed the relation between meat consumption and colorectal cancer. We conducted electronic searches of MEDLINE, EMBASE, and CANCERLIT databases through to the end of June 1999 and manual searches of references from retrieved articles. We used both fixed and random-effects meta-analytical techniques to estimate the overall association and toinvestigate possible sources of heterogeneity among studies. Thirteen studies were eligible for inclusion in the meta-analysis, Pooled results indicate that a daily increase of 100 g of all meat or red meat is associated with a significant 12-17% increased risk of colorectal cancer. The marginally significant between-study heterogeneity for all meat and red meat was explained by a number of study-level covariates, A significant 49% increased risk was found for a daily increase of 25 g of processed meat. The individual study estimates for processed meat showed no detectable heterogeneity. On the basis of this quantitative review of prospective studies, the overall association between meat consumption and risk of colorectal cancer appears tobe positive, with marginal heterogeneity between studies. The finding for processed meat and data from experimental studies suggests that it may alsobe an important predictor of colorectal cancer risk. However, because onlya few of the studies reviewed here attempted to examine the independent effect of meat intake on colorectal cancer risk, the possibility that the overall association may be confounded or modified by other factors cannot be excluded.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 05:52:27