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Titolo:
Olanzapine augmentation of serotonin uptake inhibitors in obsessive-compulsive disorder: An open study
Autore:
Francobandiera, G;
Indirizzi:
Ctr Treatment Anxiety Disorders, Dept Psychiat, Morbegno, Italy Ctr Treatment Anxiety Disorders Morbegno Italy sychiat, Morbegno, Italy
Titolo Testata:
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
fascicolo: 4, volume: 46, anno: 2001,
pagine: 356 - 358
SICI:
0706-7437(200105)46:4<356:OAOSUI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND; CLOZAPINE; FLUVOXAMINE; RISPERIDONE; PLACEBO; FLUOXETINE; EFFICACY; SYMPTOMS;
Keywords:
obsessive-compulsive disorder; olanzapine; selective serotonin reuptake inhibitors; combination drug therapy; treatment outcome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Francobandiera, G Azienda Sanit Locale Prov Sondrio, Presidio Morbegno, Piazza S Antonio 2, I-23017 Morbegno, SO, Italy Azienda Sanit Locale Prov Sondrio Piazza S Antonio 2 Morbegno SO Italy I-23017
Citazione:
G. Francobandiera, "Olanzapine augmentation of serotonin uptake inhibitors in obsessive-compulsive disorder: An open study", CAN J PSY, 46(4), 2001, pp. 356-358

Abstract

Objective: This study evaluates the clinical response to olanzapine used in association with selective serotonin reuptake inhibitors (SSRIs) ol clomipramine in treatment-resistant obsessive-compulsive disorder (OCD). Methods: We describe the cases of 9 patients with serotonin uptake inhibitor-resistant OCD who were given an open-label adjunctive treatment of olazapine for a minimum of 6 weeks. The response was assessed by using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the Clinical Global Impression Scale (CGI). Results: Six patients showed improvement of symptoms after the augmentation with olanzapine. One patient (treated with clomipramine) discontinued olanzapine due to side effects, and another. 2 did nor respond. Conclusion: Olanzapine augmentation of SSRIs in treating OCD showed a good(two-thirds), response rate, and it could therefore be considered as a treatment option when conventional therapies have failed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:24:50