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Titolo:
Antipsychotic polypharmacy: A survey of discharge prescriptions from a tertiary care psychiatric institution
Autore:
Procyshyn, RM; Kennedy, NB; Tse, G; Thompson, B;
Indirizzi:
Riverview Hosp, Div Med Serv, Port Coquitlam, BC V3C 4J2, Canada RiverviewHosp Port Coquitlam BC Canada V3C 4J2 itlam, BC V3C 4J2, Canada Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC V5Z 1M9, Canada Univ British Columbia Vancouver BC Canada V5Z 1M9 ver, BC V5Z 1M9, Canada Univ British Columbia, Fac Med, Dept Psychiat, Vancouver, BC V5Z 1M9, Canada Univ British Columbia Vancouver BC Canada V5Z 1M9 ver, BC V5Z 1M9, Canada
Titolo Testata:
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
fascicolo: 4, volume: 46, anno: 2001,
pagine: 334 - 339
SICI:
0706-7437(200105)46:4<334:APASOD>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRESCRIBING PSYCHOTROPIC-DRUGS; DOUBLE-BLIND; SCHIZOPHRENIC-PATIENTS; TARDIVE-DYSKINESIA; PARTIAL RESPONDERS; CLOZAPINE; AUGMENTATION; RISPERIDONE; HOSPITALS;
Keywords:
schizophrenia; antipsychotics; polypharmacy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Procyshyn, RM Riverview Hosp, Div Med Serv, 422 Henry Esson Young Bldg,500Lougheed Highway, Port Coquitlam, BC V3C 4J2, Canada Riverview Hosp 422 Henry Esson Young Bldg,500 Lougheed Highway Port Coquitlam BC Canada V3C 4J2
Citazione:
R.M. Procyshyn et al., "Antipsychotic polypharmacy: A survey of discharge prescriptions from a tertiary care psychiatric institution", CAN J PSY, 46(4), 2001, pp. 334-339

Abstract

Objective: To perform a retrospective survey of discharge medications at atertiary care psychiatric facility and to assess the incidence of antipsychotic polypharmacy. Method: This is a retrospective survey that used the Department of Pharmacy's computer database to obtain relevant discharge information on all nongeriatric patients with schizophrenia discharged from Riverview Hospital between November 1, 1996 and October 31, 1998. From a total of 492 eligible patients, 229 met the inclusion criteria and formed the database for the survey. Results: The main finding of the survey was that 27.5% of our discharged patients diagnosed with schizophrenia left our facility on an antipsychotic polypharmacy regimen. Compared with patients discharged on a single antipsychotic, the pooled data revealed a significantly greater use of anticholinergic agents in those patients prescribed an antipsychotic polypharmacy regimen. Further, of the atypical agents, only risperidone showed a statistically significant reduction in dosage when coprescribed with second antipsychotic. Conclusion: Although antipsychotic polypharmacy persists today, as it has over the past 30 years, evidence-based data to support this controversial treatment strategy is lacking. As a result clinicians are relying on their clinical experience, and perhaps intuition, to design antipsychotic polypharmacy treatment protocols. Efforts should be made to replace subjective clinical impression with a more rational approach to antipsychotic polypharmacy-one that is based on pharmacodynamic and pharmacokinetic understanding of drug action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:34:22