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Titolo:
Structural brain abnormalities associated with deletion at chromosome 22q11 - Quantitative neuroimaging study of adults with velo-cardio-facial syndrome
Autore:
Van Amelsvoort, T; Daly, E; Robertson, D; Suckling, J; Ng, V; Critchley, H; Owen, MJ; Henry, J; Murphy, KC; Murphy, DGM;
Indirizzi:
Inst Psychiat, Dept Psychol Med, London SE5 8AF, England Inst Psychiat London England SE5 8AF sychol Med, London SE5 8AF, England
Titolo Testata:
BRITISH JOURNAL OF PSYCHIATRY
, volume: 178, anno: 2001,
pagine: 412 - 419
SICI:
0007-1250(200105)178:<412:SBAAWD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNDROME CRITICAL REGION; VELOCARDIOFACIAL-SYNDROME; TISSUE CLASSIFICATION; MR-IMAGES; SCHIZOPHRENIA; ANOMALIES; DISORDERS; PSYCHOSIS; GENE; INTELLIGENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Van Amelsvoort, T Inst Psychiat, Dept Psychol Med, De Crespigny Pk, LondonSE5 8AF, England Inst Psychiat De Crespigny Pk London England SE5 8AF nd
Citazione:
T. Van Amelsvoort et al., "Structural brain abnormalities associated with deletion at chromosome 22q11 - Quantitative neuroimaging study of adults with velo-cardio-facial syndrome", BR J PSYCHI, 178, 2001, pp. 412-419

Abstract

Background Velo-cardio-facial syndrome (VCFS) is associated with deletionsin the pi I band of chromosome 22, learning disability and psychosis, but the neurobiological basis is poorly understood. Aims To investigate brain anatomy in adults with VCFS. Method Magnetic resonance imaging was used to study 10 patients with VCFS and 13 matched controls. We carried out three analyses: qualitative; tracedregional brain volume; and measurement of grey and white matter volume. Results The subjects with VCFS had: a high prevalence of white matter hyperintensities and abnormalities of the septum pellucidum; a significantly smaller volume of cerebellum; and widespread differences in white matter bilaterally and regional specific differences in grey matter in the left cerebellum insula, and frontal and right temporal lobes. Conclusions Deletion at chromosome 22qll is associated with brain abnormalities that are most likely neurodevelopmental tal and may partially explainthe high prevalence of learning disability and psychiatric disorder in VCFS. Declaration of interest This study was funded partially by the-Theodore and Vada Stanley Foundation and the Medical Research Council.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 03:55:29