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Titolo:
The effectiveness of the levonorgestrel-releasing intrauterine system in menorrhagia: a systematic review
Autore:
Stewart, A; Cummins, C; Gold, L; Jordan, R; Phillips, W;
Indirizzi:
Univ Birmingham, Dept Publ Hlth & Epidemiol, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT W Midlands, England Univ Birmingham, Hlth Serv Management Ctr, Hlth Econ Facil, Birmingham B152TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B152TT W Midlands, England
Titolo Testata:
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
fascicolo: 1, volume: 108, anno: 2001,
pagine: 74 - 86
SICI:
1470-0328(200101)108:1<74:TEOTLI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MENSTRUAL BLOOD-LOSS; TRANSCERVICAL ENDOMETRIAL RESECTION; QUALITY-OF-LIFE; RANDOMIZED COMPARATIVE TRIAL; RISK-BENEFIT ASSESSMENT; 20 MCG/DAY DEVICES; T-COPPER DEVICE; ABDOMINAL HYSTERECTOMY; CONTRACEPTIVE DEVICES; CLINICAL-PERFORMANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Stewart, A Univ Birmingham, Dept Publ Hlth & Epidemiol, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT England
Citazione:
A. Stewart et al., "The effectiveness of the levonorgestrel-releasing intrauterine system in menorrhagia: a systematic review", BR J OBST G, 108(1), 2001, pp. 74-86

Abstract

Objective To determine whether the levonorgestrel-releasing intrauterine device (LNG-IUS). licensed at present for contraceptive use, may reduce menstrual blood loss with few side effects. If effective, surgery could be avoided with consequent resource savings. Methods A systematic review addressing the effectiveness and cost effectiveness of the LNG-IUS for menorrhagia was undertaken. Results Five controlled trials and five case series were found which measured menstrual blood loss. Nine studies recorded statistically significant average menstrual blood loss reductions with LNG-IUS (range 74%-97%). Another showed reduction in menstrual disturbance score. The LNG-IUS was mere effective than tranexamic acid, but slightly less effective than endometrial resection at reducing menstrual blued loss, In one study, 64% of women cancelled surgery at six months, compared with 14% of control group women. In another, 82% were taken off surgical waiting lists at one year. No cost effectiveness studies were found. Discussion Small studies of moderate quality indicate the LNG-IUS is an effective treatment fur menorrhagia. Costs may be less than for tranexamic acid in primary and secondary care. Although its use may reduce surgical waiting lists, cost effectiveness assessment requires longer follow up. Conclusion Effectiveness and cost effectiveness relative to other treatments and the effect on surgical waiting lists can only be established in larger trials measuring patient-centred outcomes in women with menorrhagia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 21:41:43