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Titolo:
Postpartum intrauterine pressure studies of the uterotonic effect of oral misoprostol and intramuscular syntometrine
Autore:
Chong, YS; Chua, S; El-Refaey, H; Choo, WL; Chanrackakul, B; Tai, BC; Rodeck, C; Arulkumaran, S;
Indirizzi:
Natl Univ Singapore, Dept Obstet & Gynaecol, Singapore 0511, Singapore Natl Univ Singapore Singapore Singapore 0511 , Singapore 0511, Singapore Natl Med Res Council, Clin Trials & Epidemiol Res Unit, Singapore, Singapore Natl Med Res Council Singapore Singapore Res Unit, Singapore, Singapore Univ Coll London, Sch Med, Dept Obstet & Gynaecol, London W1N 8AA, EnglandUniv Coll London London England W1N 8AA ynaecol, London W1N 8AA, England
Titolo Testata:
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
fascicolo: 1, volume: 108, anno: 2001,
pagine: 41 - 47
SICI:
1470-0328(200101)108:1<41:PIPSOT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED TRIAL; 3RD STAGE; RECTAL MISOPROSTOL; RANDOMIZED TRIAL; UTERINE ACTIVITY; LABOR; HEMORRHAGE; PREVENTION; MANAGEMENT; METHYLERGOMETRINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Chong, YS Natl Univ Singapore Hosp, Dept Obstet & Gynaecol, Lower Kent Ridge Rd, Singapore 119074, Singapore Natl Univ Singapore Hosp Lower Kent Ridge Rd Singapore Singapore 119074
Citazione:
Y.S. Chong et al., "Postpartum intrauterine pressure studies of the uterotonic effect of oral misoprostol and intramuscular syntometrine", BR J OBST G, 108(1), 2001, pp. 41-47

Abstract

Objectives To investigate the effect of oral misoprostol in dosages varying from 200 mug to 800 mug on post partum uterine contractility and to establish their side effects. Design A prospective descriptive study. Participants Fifty-seven women who delivered vaginally after spontaneous labours not requiring augmentation. Methods Within 5 minutes of delivery of the placenta, a calibrated Gaelteccatheter with an intrauterine pressure transducer at its tip was inserted transcervically into the uterine cavity. Cumulative uterine activity was recorded for 30 minutes in each woman before administering the oral misoprostol tablets and continued for a further 90 minutes after its administration. Thus each woman acted as her own control regarding changes in uterine contractility. Uterine activity was recorded on a Sonicaid Meridian fetal monitor, which measures active contraction area automatically. The incidence of side effects was also recorded. Results There was no statistical difference (P = 9.837) in the adjusted mean difference in cumulative uterine activity following all the doses of oral misoprostol, compared with intramuscular syntometrine, the largest difference being seen in oral misoprostol 200 mug (adjusted mean difference -2282kPas s, 95% CI -7954 to 3390 kPas s). The mean onset of action of oral misoprostol (6.1, SD 2.1 min) was significantly slower than that of intramuscular syntometrine (3.2, SD 1.5 min; P = 0.002), but their durations of action were similar (P = 0.637). In the misoprostol group the commonest side effects were shivering (36%) and a rise in body temperature above 38 degreesC (40%). In the syntometrine group, the most commonly observed side effect was moderate uterine pain (nine out of ten women) and a rise in diastolic blood pressure of 20 mmHg (two out of ten women). Conclusion The results of this study show that oral misoprostol has a definite uterotonic effect on the postpartum uterus. At doses of 200 mug to 100mug, oral misoprostol has a similar uterotonic effect to intramuscular syntometrine. Higher doses of oral misoprostol are associated with significantly more side effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:40:11