Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Oxytocics reverse the tocolytic effect of glyceryl trinitrate an the humanuterus
Autore:
Lau, LC; Adaikan, PG; Arulkumaran, S; Ng, SC;
Indirizzi:
Natl Univ Singapore Hosp, Dept Obstet & Gynaecol, Singapore 119074, Singapore Natl Univ Singapore Hosp Singapore Singapore 119074 re 119074, Singapore Univ Nottingham, Derby City Gen Hosp, Acad Div Obstet & Gynaecol, Derby, England Univ Nottingham Derby England cad Div Obstet & Gynaecol, Derby, England
Titolo Testata:
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
fascicolo: 2, volume: 108, anno: 2001,
pagine: 164 - 168
SICI:
1470-0328(200102)108:2<164:ORTTEO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC GUANOSINE-MONOPHOSPHATE; VASCULAR SMOOTH-MUSCLE; NITRIC-OXIDE; INTRAVENOUS NITROGLYCERIN; UTERINE RELAXATION; ENDOTHELIAL-CELLS; NITROPRUSSIDE; PLACENTA; LABOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Adaikan, PG Natl Univ Singapore Hosp, Dept Obstet & Gynaecol, Lower Kent Ridge Rd, Singapore 119074, Singapore Natl Univ Singapore Hosp Lower Kent Ridge Rd Singapore Singapore 119074
Citazione:
L.C. Lau et al., "Oxytocics reverse the tocolytic effect of glyceryl trinitrate an the humanuterus", BR J OBST G, 108(2), 2001, pp. 164-168

Abstract

Objectives To investigate the effect of glyceryl trinitrate on isolated human pregnant uterine strips and whether the uterine relaxation induced by glyceryl trinitrate could be reversed by oxytocics used in current clinical practice. Design In vitro pharmacological study. Setting Department of Obstetrics & Gynaecology, National University of Singapore, National University Hospital. Participants Eighteen women who delivered by caesarean section at term. Methods Myometrial strips were preloaded with an initial tension of 1.5g in organ baths containing Krebs-Henseleit solution which was aerated with oxygen in 5% carbon dioxide and maintained at 37 degreesC, pH 7.4. The effectof glyceryl trinitrate was studied in strips displaying regular spontaneous contractions. The ability of oxytocin, ergometrine or prostaglandin F-2 alpha to stimulate uterine contractions was assessed in strips where uterineactivity was significantly inhibited by glyceryl trinitrate. Results Glyceryl trinitrate reduced the amplitude and frequency of spontaneous uterine contractions in a concentration-dependent manner. although thesensitivity of the myometrial strips varied considerably from one specimento another. The concentration of glyceryl trinitrate producing complete inhibition of myometrial contractions ranged from 44-705 muM. In the presenceof glyceryl trinitrate which markedly depressed spontaneous contractions, osytocin (20mU/mL), ergometrine (6.15 muM) and prostaglandin F-2 alpha (6.15 muM) were capable of reversing the uterine activity to either higher thanor the untreated level of contractility. Conclusions This study demonstrates that glyceryl trinitrate is a potent uterine relaxant in vitro and that the tocolytic effect could be reversed with ease by osytocics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:32:50