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Titolo:
Circulatory responses to maternal hyperoxaemia and hypoxaemia assessed non-invasively in fetal sheep at 0.3-0.5 gestation in acute experiments
Autore:
Kiserud, T; Jauniaux, E; West, D; Ozturk, O; Hanson, MA;
Indirizzi:
Royal Free & Univ Coll, Sch Med, Dept Obstet & Gynaecol, London, England Royal Free & Univ Coll London England bstet & Gynaecol, London, England
Titolo Testata:
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
fascicolo: 4, volume: 108, anno: 2001,
pagine: 359 - 364
SICI:
1470-0328(200104)108:4<359:CRTMHA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
VELOCITY WAVE-FORMS; DUCTUS VENOSUS; BLOOD-FLOW; CARDIOVASCULAR-RESPONSES; HEART-RATE; HYPEROXYGENATION; HYPOXEMIA; PREGNANCIES; VELOCIMETRY; PREDICTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kiserud, T Bergen Univ Hosp, Dept Obstet & Gynaecol, Unit Fetal Med, POB 1, N-5021 Bergen, Norway Bergen Univ Hosp POB 1 Bergen Norway N-5021 021 Bergen, Norway
Citazione:
T. Kiserud et al., "Circulatory responses to maternal hyperoxaemia and hypoxaemia assessed non-invasively in fetal sheep at 0.3-0.5 gestation in acute experiments", BR J OBST G, 108(4), 2001, pp. 359-364

Abstract

Objectives To determine fetal haemodynamic responses to hyperoxaemia and hypoxaemia in early pregnancy. Design Repeated measurements in acute experiments. Setting Experimental physiology laboratory. Methods Non-invasive Doppler ultrasound of the umbilical vein, ductus venosus, umbilical and common carotid arteries of 12 fetal lambs (0.27-0.56 gestation) during maternal hyperoxaemia and hypoxaemia under ketamine anaesthesia. The effect of gestational age, hyperoxaemia, and hypoxaemia were assessed based on analysis of variance for dependent measurements and P less than or equal to 0.05 was considered significant. Differences between groups were considered significant if the 95% confidence interval did not include zero. Results Gestational age had a significant effect on the blood velocity in the umbilical vein and ductus venosus. There were no circulatory changes during hyperoxaemia, but a simultaneous increase of pCO(2) was an important confounder. However, hypoxaemia caused significantly reduced heart rate, reduced maximum and weighted mean blood velocity, and augmented pulsation in the umbilical vein. Hypoxaemia also caused reduced Velocities in the ductus venosus (peak velocity during systole and minimum during diastole, and time-averaged velocity) and augmented pulsation of the flow velocity. Additionally, the pulsatility of blood flow increased in the umbilical artery and was reduced in the common carotid artery. Conclusions Maternal hypoxaemia in early pregnancy causes similar fetal circulatory responses to those in late pregnancy: bradycardia, reduced venousflow velocities, augmented pulsatility in veins and a redistributional flow velocity pattern of the umbilical and common carotid arteries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:57:27