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Titolo:
Effects of morphine on pentobarbital-induced responses in mu-opioid receptor knockout mice
Autore:
Park, Y; Ho, IK; Jang, CG; Tanaka, S; Ma, T; Loh, HH; Ko, KH;
Indirizzi:
Seoul Natl Univ, Coll Pharm, Dept Pharmacol, Kwanak Gu, Seoul 151742, South Korea Seoul Natl Univ Seoul South Korea 151742 k Gu, Seoul 151742, South Korea Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, Jackson, MS 39216 USAUniv Mississippi Jackson MS USA 39216 ol & Toxicol, Jackson, MS 39216 USA Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 rmacol, Minneapolis, MN 55455 USA
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 5, volume: 54, anno: 2001,
pagine: 527 - 531
SICI:
0361-9230(20010315)54:5<527:EOMOPR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIAQUEDUCTAL GRAY; GABAERGIC NEURONS; INDUCED ANALGESIA; RAT; ANTAGONISTS; ANTINOCICEPTION; TEMPERATURE; WITHDRAWAL; MECHANISMS; RELEASE;
Keywords:
mu-opioid receptor knockout mice; pentobarbital; morphine; potentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Ko, KH Seoul Natl Univ, Coll Pharm, Dept Pharmacol, Kwanak Gu, Seoul 151742, South Korea Seoul Natl Univ Seoul South Korea 151742 eoul 151742, South Korea
Citazione:
Y. Park et al., "Effects of morphine on pentobarbital-induced responses in mu-opioid receptor knockout mice", BRAIN RES B, 54(5), 2001, pp. 527-531

Abstract

Effects of morphine on the potentiation of pentobarbital-induced responseswere investigated using mu -opioid receptor knockout mice. The duration ofloss of righting reflex, hypothermia, and loss of motor coordination induced by pentobarbital were measured after pretreatment with either morphine or saline. Morphine pretreatment failed to show potentiation of both pentobarbital-induced loss of righting reflex and hypothermia in mu -opioid receptor knockout mice, while it significantly potentiated these responses in thewild-type controls. For motor incoordination test, morphine potentiated pentobarbital-induced motor incoordination in the wild-type mice. However, morphine may have opposite effects in the mu -opioid receptor knockout mice. These results demonstrate that synergism between morphine and pentobarbitalis not detected in mu -opioid receptor knockout mice and that potentiationof pentobarbital-induced loss of righting reflex and hypothermia by morphine is mediated through mu -opioid receptor. It was interesting to note thatpentobarbital-induced decrease in body temperature was less severe in mu -opioid receptor knockout mice than in wild-type mice. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 03:49:52