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Titolo:
Further evidence for a significant participation of the melanocortin 4 receptor in the preovulatory prolactin surge in the rat
Autore:
Watanobe, H; Yoneda, M; Kakizaki, Y; Kohsaka, A; Suda, T; Schioth, HB;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Internal Med 3, Hirosaki, Aomori, Japan Hirosaki Univ Hirosaki Aomori Japan ernal Med 3, Hirosaki, Aomori, Japan Dokkyo Univ, Sch Med, Dept Gastroenterol, Mibu, Tochigi 32102, Japan Dokkyo Univ Mibu Tochigi Japan 32102 oenterol, Mibu, Tochigi 32102, Japan Uppsala Univ, Dept Neurosci, Uppsala, Sweden Uppsala Univ Uppsala Sweden ppsala Univ, Dept Neurosci, Uppsala, Sweden Melacure Therapeut, Uppsala, Sweden Melacure Therapeut Uppsala SwedenMelacure Therapeut, Uppsala, Sweden
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 5, volume: 54, anno: 2001,
pagine: 521 - 525
SICI:
0361-9230(20010315)54:5<521:FEFASP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; MOLECULAR-CLONING; NEUROENDOCRINE REGULATION; LUTEINIZING-HORMONE; BETA-ENDORPHIN; FOOD-INTAKE; PROOPIOMELANOCORTIN NEURONS; PRO-OPIOCORTIN; MC4 RECEPTOR; BODY-WEIGHT;
Keywords:
melanocortin system; central nervous system; reproductive axis; neuroendocrine action;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Watanobe, H Int Univ Hlth & Welf, Clin Res Ctr, Div Internal Med, 2600-1 Kitakanemaru,Otawara, Tochigi 3248501, Japan Int Univ Hlth & Welf 2600-1 Kitakanemaru Otawara Tochigi Japan 3248501
Citazione:
H. Watanobe et al., "Further evidence for a significant participation of the melanocortin 4 receptor in the preovulatory prolactin surge in the rat", BRAIN RES B, 54(5), 2001, pp. 521-525

Abstract

We previously reported that the melanocortin 4 receptor may play a significant role in mediating the preovulatory surges of luteinizing hormone and prolactin in the rat. In order to confirm this previous finding, in the present study we examined and compared the effects of intracerebroventricular administrations of 1.0 nmol of MT II (a non-selective melanocortin 3 and 4 receptor agonist) and 10 nmol of gamma (1)-melanocytestimulating hormone (a selective melanocortin 3 receptor agonist) on luteinizing hormone and prolactin surges in starved, gonadal steroid-primed ovariectomized female rats, which is a model deprived of inherent surges of the two hormones. MT II significantly recovered the surge of prolactin, but not of luteinizing hormone(although a tendency to increase was seen), and gamma (1)-melanocyte-stimulating hormone was without effect on both hormones. This study corroboratedour previous report through a different and direct approach that the melanocortin 4 receptor, but not the melanocortin 3 receptor, plays a significant role in mediating the preovulatory prolactin surge in the rat. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 06:56:17