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Titolo:
Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sitesin beagles
Autore:
Mashiba, T; Turner, CH; Hirano, T; Forwood, MR; Johnston, CC; Burr, DB;
Indirizzi:
Indiana Univ, Sch Med, Dept Anat & Cell Biol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 l Biol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Orthoped Surg, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 d Surg, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Biomech, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 iomech, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Biomat Res Ctr, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 es Ctr, Indianapolis, IN 46202 USA Kariwa Gun Gen Hosp, Dept Orthopaed Surg, Niigata, Japan Kariwa Gun Gen Hosp Niigata Japan , Dept Orthopaed Surg, Niigata, Japan Univ Queensland, Dept Anat Sci, Brisbane, Qld, Australia Univ Queensland Brisbane Qld Australia nat Sci, Brisbane, Qld, Australia Indiana Univ, Sch Med, Dept Med, Indianapolis, IN USA Indiana Univ Indianapolis IN USA Sch Med, Dept Med, Indianapolis, IN USA
Titolo Testata:
BONE
fascicolo: 5, volume: 28, anno: 2001,
pagine: 524 - 531
SICI:
8756-3282(200105)28:5<524:EOSBTB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRACTURE INTERVENTION TRIAL; VERTEBRAL FRACTURES; ALENDRONATE; WOMEN; RISK; OSTEOPOROSIS; FATIGUE; DAMAGE;
Keywords:
microdamage; bone remodeling; bisphosphonate; biomechanics; histomorphometry; dog;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Burr, DB Indiana Univ, Sch Med, Dept Anat & Cell Biol, Med Sci Bldg 5035, Indianapolis, IN 46202 USA Indiana Univ Med Sci Bldg 5035 Indianapolis IN USA 46202 6202 USA
Citazione:
T. Mashiba et al., "Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sitesin beagles", BONE, 28(5), 2001, pp. 524-531

Abstract

We recently demonstrated that suppression of bone remodeling allows microdamage to accumulate, leading to reduced bone toughness in the rib cortex ofdogs. This study evaluates the effects of reduced bone turnover produced by bisphosphonates on microdamage accumulation and biomechanical properties at clinically relevant skeletal sites in the same dogs. Thirty-six female beagles, 1-2 years old, were divided into three groups. The control group was treated daily for 12 months with saline vehicle (CNT), The remaining two groups were treated daily with risedronate at a dose of 0.5 mg/kg per day (RIS), or alendronate at 1.0 mg/kg per day (ALN) orally, The doses of these bisphosphonates were six times the clinical doses approved for treatment ofosteoporosis in humans. After killing, the L-1 vertebra was scanned by dual-energy X-ray absorptiometry (DXA), and the L-2 vertebra and right ilium were assigned to histomorphometry, The L-3 vertebra, left ilium, Th-2 spinous process, and right femoral neck were used for microdamage analysis. The L-4 vertebra and Th-1 spinous process were mechanically tested to failure incompression and shear, respectively. One year treatment with risedronate or alendronate significantly suppressed trabecular remodeling in vertebrae (RIS 90%, ALN 95%) and ilium (RIS 76%, ALN 90%) without impairment of mineralization, and significantly increased microdamage accumulation in all skeletal sites measured. Trabecular bone volume and vertebral strength increasedsignificantly following 12 month treatment. However, normalized toughness of the L-4 vertebra was reduced by 21% in both RIS (p = 0.06) and ALN (p = 0.05) groups. When the two bisphosphonate groups were pooled in a post hoc fashion for analysis, this reduction in toughness reached statistical significance (p = 0.02), This study demonstrates that suppression of trabecular bone turnover by high doses of bisphosphonates is associated with increasedvertebral strength, even though there is significant microdamage accumulation and a reduction in the intrinsic energy absorption capacity of trabecular bone. (C) 2001 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:35:30