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Titolo:
Side-effects of oral or intravesical oxybutynin chloride in children with spina bifida
Autore:
Ferrara, P; DAleo, CM; Tarquini, E; Salvatore, S; Salvaggio, E;
Indirizzi:
Catholic Univ Sacred Heart, Dept Paediat, I-00168 Rome, Italy Catholic Univ Sacred Heart Rome Italy I-00168 ediat, I-00168 Rome, Italy Milan Bicocca Univ, Bassini Hosp, Milan, Italy Milan Bicocca Univ Milan Italy Bicocca Univ, Bassini Hosp, Milan, Italy
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 7, volume: 87, anno: 2001,
pagine: 674 - 677
SICI:
1464-4096(200105)87:7<674:SOOOIO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROGENIC BLADDER DYSFUNCTION; DETRUSOR HYPERREFLEXIA; MYELOMENINGOCELE; PHARMACOKINETICS; INFANTS; LESS;
Keywords:
neurogenic bladder; oxybutynin; side-effects; cognitive impairment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Ferrara, P Catholic Univ Sacred Heart, Dept Paediat, Largo A Gemelli 8, I-00168 Rome,Italy Catholic Univ Sacred Heart Largo A Gemelli 8 Rome Italy I-00168
Citazione:
P. Ferrara et al., "Side-effects of oral or intravesical oxybutynin chloride in children with spina bifida", BJU INT, 87(7), 2001, pp. 674-677

Abstract

Objective To evaluate the incidence of side-effects of oral and intravesical oxybutynin chloride in children with meningomyelocele (MMC) and a neurogenic bladder. Patients and methods The study comprised 225 children with a neurogenic bladder from MMC who were evaluated with urodynamic testing and voiding cystourethrography to identify those at high risk of upper tract damage. In all,101 children (mean age 4.2 years, range 0.25-10) had unco-ordinated detrusor-sphincter function and low compliance: they were treated with either oral or intravesical oxybutynin and clean intermittent catheterization. Results Of the 101 patients, 67 were treated with oral oxybutynin: in 11 the treatment was discontinued because of the side-effects. The other 34 patients used both clean intermittent catheterization and intravesical oxybutynin. In this group there were side-effects in six patients, including drowsiness, hallucinations and cognitive changes. Conclusions Oral and intravesical oxybutynin is effective for managing neurogenic bladder dysfunction, but intravesical administration is safer and better tolerated than oral oxybutynin in the treatment of children with MMC. However, adverse effects such as cognitive impairment can also occur in children treated with intravesical oxybutynin and these patients must be closely monitored because these effects may differ from those with oral administration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:32:43