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Titolo:
Does age influence the behaviour of localized prostate cancer?
Autore:
Parker, CC; Gospodarowicz, M; Warde, P;
Indirizzi:
Princess Margaret Hosp, Dept Radiat Oncol, Toronto, ON M5G 2M9, Canada Princess Margaret Hosp Toronto ON Canada M5G 2M9 onto, ON M5G 2M9, Canada
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 7, volume: 87, anno: 2001,
pagine: 629 - 637
SICI:
1464-4096(200105)87:7<629:DAITBO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTERNAL-BEAM RADIATION; RADICAL RETROPUBIC PROSTATECTOMY; DISEASE-FREE SURVIVAL; LONG-TERM SURVIVAL; PROGNOSTIC FACTOR; CONSERVATIVE MANAGEMENT; CLINICAL STAGE; WHITE MEN; CARCINOMA; THERAPY;
Keywords:
meta-analysis; prostate cancer; age; outcome; localized;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Parker, CC Princess Margaret Hosp, Dept Radiat Oncol, 620 Univ Ave, Toronto, ON M5G 2M9, Canada Princess Margaret Hosp 620 Univ Ave Toronto ON CanadaM5G 2M9 a
Citazione:
C.C. Parker et al., "Does age influence the behaviour of localized prostate cancer?", BJU INT, 87(7), 2001, pp. 629-637

Abstract

Objective To assess, in a meta-analysis of published studies, whether age influences the behavior of localized prostate cancer. Methods The Medline database was searched from 1966 to 2000 to identify studies analysing the outcome of localized prostate cancer by age, using disease-specific outcome measures, and having controlled for the established prognostic factors of grade, T stage and, where available, serum prostate-specific antigen (PSA) level. Results In all, 34 studies were identified, which included a total of 27 551 patients. The incomplete and heterogeneous nature of the reports precluded any quantitative overview. The findings of these reports are described and methodological shortcomings discussed. Conclusion The evidence suggests that young age was an adverse prognostic factor in some series of radiation therapy before the advent of PSA assays,when men typically presented clinically with locally advanced disease, butthat age has no significant prognostic effect in contemporary series of localized prostate cancer. Possible explanations for this difference are discussed, together with implications for further studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:54:00