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Titolo:
Chronic effects of ACE-inhibition (quinapril) and angiotensin-II type-1 receptor blockade (losartan) on atrial natriuretic peptide in brain nuclei ofrats with experimental myocardial infarction
Autore:
Hu, K; Bahner, U; Gaudron, P; Palkovits, M; Ring, M; Fehle, A; Kruse, B; Ertl, G;
Indirizzi:
Univ Wurzburg, Med Univ Klin, D-98080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-98080 v Klin, D-98080 Wurzburg, Germany Univ Heidelberg, Klinikum Mannheim, D-68167 Mannheim, Germany Univ Heidelberg Mannheim Germany D-68167 heim, D-68167 Mannheim, Germany Semmelweis Univ, Sch Med, Dept Anat, H-1094 Budapest, Hungary Semmelweis Univ Budapest Hungary H-1094 t Anat, H-1094 Budapest, Hungary
Titolo Testata:
BASIC RESEARCH IN CARDIOLOGY
fascicolo: 3, volume: 96, anno: 2001,
pagine: 258 - 266
SICI:
0300-8428(200105/06)96:3<258:CEOA(A>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME-INHIBITION; SPONTANEOUSLY HYPERTENSIVE RATS; 3RD VENTRICLE AV3V; SUBFORNICAL ORGAN; ANTAGONIST LOSARTAN; NERVOUS-SYSTEM; HEART-FAILURE; BINDING-SITES; SURVIVAL; AUTORADIOGRAPHY;
Keywords:
angiotensin converting enzyme inhibition; Ang II; blood-brain barrier; ANP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Ertl, G Univ Wurzburg, Med Univ Klin, Josef Schneider Str 2, D-98080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-98080 many
Citazione:
K. Hu et al., "Chronic effects of ACE-inhibition (quinapril) and angiotensin-II type-1 receptor blockade (losartan) on atrial natriuretic peptide in brain nuclei ofrats with experimental myocardial infarction", BAS R CARD, 96(3), 2001, pp. 258-266

Abstract

Alterations of the central nervous system may be important for imbalance of cardiovascular and fluid regulation in heart failure. The central renin-angiotensin and atrial natriuretic peptide (ANP) systems act as mutual antagonists. The effects of angiotensin converting enzyme (ACE) inhibition (quinapril, 6 mg/kg/day) and angiotensin II type 1 (AT,) receptor blockade (losartan, 10 mg/kg/day) on ANP levels in 18 selected, microdissected brain nuclei were determined in sham-operated rats and rats with left ventricular dysfunction 8 weeks after myocardial infarction (MI). Plasma ANP tended to increase in MI rats and was further increased by quinapril. ANP was decreased in 12 brain areas of MI rats. ANP concentration was also significantly decreased by quinapril in six brain nuclei including subfornical organ and organum vasculosum laminae terminalis (areas lacking blood-brain barrier), and by losartan in 16 brain nuclei outside and within the blood-brain barrier in sham operated rats. However, both quinapril and losartan prevented a further reduction of central ANP as a result of myocardial infarction. These data suggest that there are effects on central ANP that result from chronic left ventricular dysfunction as well as an ACE-inhibitor and AT,antagonist. Mechanisms and consequences of central ANP depression remain unclear. They could, however, support systemic vasoconstriction and sodium and fluid retention.

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Documento generato il 22/01/20 alle ore 12:34:06