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Titolo:
Somatosensory nociceptive mechanical stimulation modulates systemic and mesenteric microvascular hemodynamics in anesthetized rats
Autore:
Yamaguchi, S; Ito, M; Ohshima, N;
Indirizzi:
Univ Tsukuba, Inst Basic Med Sci, Dept Biomed Engn, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 3, volume: 88, anno: 2001,
pagine: 160 - 166
SICI:
1566-0702(20010514)88:3<160:SNMSMS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUPUNCTURE-LIKE STIMULATION; ELECTROACUPUNCTURE STIMULATION; ADRENERGIC NERVES; BLOOD-FLOW; HINDLIMB; RESPONSES; VESSELS;
Keywords:
pinch stimulus; microcirculation; hemodynamics; blood flow velocity; mesenteric arteriole; sympathetic reflex; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Ohshima, N Univ Tsukuba, Inst Basic Med Sci, Dept Biomed Engn, 1-1-1 Tennoudai,Tsukuba Sci City, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba 1-1-1 Tennoudai,Tsukuba Sci City Tsukuba Ibaraki Japan 3058575
Citazione:
S. Yamaguchi et al., "Somatosensory nociceptive mechanical stimulation modulates systemic and mesenteric microvascular hemodynamics in anesthetized rats", AUTON NEURO, 88(3), 2001, pp. 160-166

Abstract

The effects of somatosensory nociceptive pinch stimulation of the hindpaw on mesenteric microvascular hemodynamics and systemic circulatory parameters were investigated in anesthetized rats using an intravital microscope-television system. Blood flow velocity in the terminal (18-40 mum in diameter)or precapillary (10-20 mum in diameter) arterioles of the mesentery was monitored by the dual sensor method developed by the authors. In the proximalterminal arterioles, blood flow velocity decreased substantially along with arteriolar constriction induced by pinching of the hindpaw for 30 s. In the distal terminal arterioles and precapillary arterioles, blood flow velocity increased after pinching. In the proximal terminal arterioles, the decrease of velocity in response to reflex vasoconstriction was abolished by intravenous injection of an alpha -blocker (phentolamine. 10 mg/kg). The increase in mesenteric precapillary arteriolar blood flow velocity (43 +/- 9%, p < 0.01) associated with the increase in mean arterial pressure (MAP) (22 /- 1%. p < 0.01) was observed within a few seconds after the onset of the stimulation, and then the response in blood flow velocity returned to the baseline ahead of MAP response recovery after the end of the stimulus. Theseresponses were diminished by alpha -adrenergic receptor blockade. The heart rate (HR) increase (4 +/- 1%, p < 0.01) induced by pinching was abolishedby beta -adrenergic receptor blockade (propranolol, 3 mg/kg, i.v.). There was a strong correlation between the increase in MAP and the decrease in renal blood flow measured by laser Doppler flowmeter ( r = 0.87-0.98). Pinch stimulation of the rat hindpaw evoked changes in mesenteric arteriolar blood flow velocity that were mediated via the somato-sympathetic reflex vasoconstriction and the presser response. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:45:42