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Titolo:
ANGIOGENESIS INHIBITOR TNP-470 AUGMENTS THE EFFECT OF REPEATED ARTERIAL ISCHEMIA ON GROWTH BUT DOES NOT AFFECT TAKE IN A RAT-LIVER TUMOR-MODEL
Autore:
MOLLER PH; IVARSSON K; ROOS G; RADNELL M; PERSSON B; TRANBERG KG; STENRAM U;
Indirizzi:
LUND UNIV,DEPT PATHOL S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT SURG S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT PATHOL S-22185 LUND SWEDEN
Titolo Testata:
Anticancer research
fascicolo: 4A, volume: 17, anno: 1997,
pagine: 2401 - 2406
SICI:
0250-7005(1997)17:4A<2401:AITATE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN COLON-CANCER; HEPATIC-ARTERY; REPEATED DEARTERIALIZATION; METASTASIS; AGM-1470; CARCINOMA;
Keywords:
RAT LIVER TUMOR; TNP-470; HEPATIC ISCHEMIA; DEARTERIALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
P.H. Moller et al., "ANGIOGENESIS INHIBITOR TNP-470 AUGMENTS THE EFFECT OF REPEATED ARTERIAL ISCHEMIA ON GROWTH BUT DOES NOT AFFECT TAKE IN A RAT-LIVER TUMOR-MODEL", Anticancer research, 17(4A), 1997, pp. 2401-2406

Abstract

Transient hepatic arterial occlusion causes necrosis in solid hepatictumors in the rat, but regrowth of tumor cells and capillaries takes place from the tumor periphery. It was therefore considered of interest to combine this treatment with the angiogenesis inhibitor TNP-470 (therapeutic model). Wistar rats with a dimethylhydrazine-induced adenocarcinoma implanted into the liver received one of the following treatments: TNP-470 + transient hepatic ischemia, transient hepatic ischemiaalone, TNP-470 alone or sham solution alone. Rats were sacrificed oneweek after the start of treatment. In addition, we investigated if TNP-470 decreases the risk of tumor take in the liver after intraportal injection of viable tumor cells (adjuvant study. Transient hepatic ischemia combined with TNP-470 gave a smaller increase in tumor volume than transient hepatic ischemia (p < 0.01), TNP-470 (p < 0.001) alone orno treatment (p < 0.001). Transient hepatic ischemia or TNP-470 caused a significant suppression of tumor growth when compared to controls (p < 0.01 in both cases). In the adjuvant study, TNP-470 caused retardation of tumor growth (p < 0.02 as compared to controls) but did not affect tumor number. It is concluded that TNP-470 suppressed tumor growth, both alone and in combination with transient hepatic ischemia, butdid not affect take of tumor.

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Documento generato il 10/07/20 alle ore 01:31:31