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Titolo:
Complications common to ventricular assist device support are rare with 90days of DeBakey VAD (R) support in calves
Autore:
Fossum, TW; Morley, D; Olsen, DB; Edwards, J; Burns, G; Miller, MW; Franks, J; Benkowski, R; Thomas, J; Benson, P; Martinez, E; Carroll, G; Lynch, B; Noon, GP; DeBakey, ME;
Indirizzi:
Texas A&M Univ, Coll Vet Med, Dept Small Anim Med & Surg, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 & Surg, College Stn, TX 77843 USA MicroMed Technol Inc, Houston, TX USA MicroMed Technol Inc Houston TX USA icroMed Technol Inc, Houston, TX USA Univ Utah, Artificial Heart Res Lab, Salt Lake City, UT USA Univ Utah Salt Lake City UT USA al Heart Res Lab, Salt Lake City, UT USA Baylor Coll Med, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 ylor Coll Med, Houston, TX 77030 USA
Titolo Testata:
ASAIO JOURNAL
fascicolo: 3, volume: 47, anno: 2001,
pagine: 288 - 292
SICI:
1058-2916(200105/06)47:3<288:CCTVAD>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIRCULATORY SUPPORT; IN-VITRO; TRANSPLANTATION; BRIDGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Fossum, TW Texas A&M Univ, Coll Vet Med, Dept Small Anim Med & Surg, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 lege Stn, TX 77843 USA
Citazione:
T.W. Fossum et al., "Complications common to ventricular assist device support are rare with 90days of DeBakey VAD (R) support in calves", ASAIO J, 47(3), 2001, pp. 288-292

Abstract

The DeBakey VAD (R) is a miniaturized, electromagnetically driven axial flow pump intended for long-term ventricular assist. Safety and performance data from six calves implanted with the complete DeBakey VAD (R) system are reported elsewhere; here we describe complications and necropsy findings for these same six animals, all of which survived 90 days. The study was conducted according to a uniform protocol, which included anticoagulation and antibiotic prophylaxis. Clinical complications tracked included bleeding, cardiovascular abnormalities (e.g., arrhythmias, tachycardia unrelated to pain, bradycardia), hemolysis, hepatic dysfunction, renal dysfunction, thromboembolism (neurologic or peripheral), or infection. Each adverse event was retrospectively categorized with regard to severity (mild, moderate, severe)and relationship to device. Clinical findings were confirmed by necropsy. There was no evidence of systemic infection, thromboembolism, hemolysis, orrenal or hepatic dysfunction in these six animals during the study period. A single adverse event was noted in each of two of the calves. Both eventswere considered mild according to the predefined criteria. Bleeding related to the surgical implantation procedure and requiring reoperation occurredin one animal. The other animal had evidence of a superficial infection atthe exit site of the cables on the left lateral thoracic wall; the infection did not extend into the thoracic cavity. Chronic, healed small renal infarct scars were present in several animals. Mild valvular endocardiosis wasobserved in two calves and mild fibroelastosis was present in the endocardium at the site of the inflow cannula in three calves; however, these lesions were not considered clinically significant No other gross or histologic abnormalities were noted at necropsy. In conclusion, calves implanted with the complete DeBakey VAD (R) for 90 days demonstrated few complications andhad no significant necropsy findings. Complications common to ventricular assist device (VAD) support (i.e., hemolysis, infection, bleeding, thromboembolism) were rare during long-term support (90 days) with the DeBakey VAD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 13:49:42