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Titolo:
Identification of a gamma-interferon-responsive element in the promoter ofthe human macrophage scavenger receptor A gene
Autore:
Grewal, T; Priceputu, E; Davignon, J; Bernier, L;
Indirizzi:
Clin Res Inst Montreal, Hyperlipidemia & Atherosclerosis Res Grp, Montreal, PQ H2W 1R7, Canada Clin Res Inst Montreal Montreal PQ Canada H2W 1R7 eal, PQ H2W 1R7, Canada
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 5, volume: 21, anno: 2001,
pagine: 825 - 831
SICI:
1079-5642(200105)21:5<825:IOAGEI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY LIPOPROTEIN; FOAM CELL-FORMATION; IFN-GAMMA; EXPRESSION; MONOCYTE; ATHEROSCLEROSIS; DIFFERENTIATION; LESIONS; ALPHA; MICE;
Keywords:
scavenger receptor type A; gamma-interferon; STAT1 alpha; GAS element; macrophage activation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Bernier, L Clin Res Inst Montreal, Hyperlipidemia & Atherosclerosis Res Grp, 110 PineAve W, Montreal, PQ H2W 1R7, Canada Clin Res Inst Montreal 110 Pine Ave W Montreal PQ Canada H2W 1R7
Citazione:
T. Grewal et al., "Identification of a gamma-interferon-responsive element in the promoter ofthe human macrophage scavenger receptor A gene", ART THROM V, 21(5), 2001, pp. 825-831

Abstract

In the present study, we demonstrate gamma -interferon (gamma -IFN)-inducible scavenger receptor A (SR-A) mRNA expression during the early stages of THP-1 and blood monocyte differentiation. Predominant induction of SR-A type II mRNA parallels the increased accumulation of cholesteryl esters under these conditions. A potential signal transducer and activator of transcription (STAT1) binding site (gamma -interferon activation site) in the SR-A promoter demonstrates gamma -IFN-inducible DNA binding activity and is most likely responsible for the gamma -IFN-dependent expression of an SR-A promoter-luciferase fusion construct. In contrast, gamma -IFN inhibits SR-A expression in mature macrophages as well as after prolonged gamma -IFN incubation of THP-1 monocytes. Taken together, these results demonstrate opposite effects of gamma -IFN on SR-A expression and activity during the early versuslate stages of monocyte maturation. gamma -IFN-induced STAT1 activation, leading to increased SR-A expression, could therefore play an important rolein the initial steps of foam cell formation and xanthomatosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 03:42:57